PXD018577

PXD018577 is an original dataset announced via ProteomeXchange.

Title	Toxicoproteomic-based screening discloses pivotal downregulated mechanisms triggered by chronic pesticide exposure in breast cancer patients.
Description	Pesticides are chemical compounds widely used in agriculture to control pests, since the 1960s. Regardless of its specific targets, such substances, unfortunately, can reach the human organism, and negative cumulative effects have been reported in people worldwide. Chronic exposure to pesticides has been discussed as a significant risk factor for the development of cancer, including breast tumors. Breast cancer is the most common malignant neoplasia that affects women worldwide, whose origin is mostly connected to life habits and the environment, and to a lesser extent to inheritable genetic mechanisms. Therefore, the contribution of substances as pesticides, that are present in the environment continuously, may have a pivotal role in the genesis breast cancer, especially in geographic areas in which women are important players in the rural work and are in direct contact with these compounds. In vitro and experimental studies have broadly reported the mechanisms triggered by pesticides that contribute to breast carcinogenesis, which fall essentially within DNA damage-based events in association with hormones deregulation and rising of metabolites that activate oncogenes (Alleva et al., 2018, BRADLOW et al., 1995). However, few is known about how these mechanisms are connected, as well as the manner that they can correlate with disease prognosis and clinicopathological features in human breast cancer as a result of the toxic consequences of pesticide exposure. In the last years, aiming to expand the knowledge about beyond isolated biological findings, high throughput molecular approaches combined with bioinformatics designs raised as powerful tools to understand breast cancer behavior and biology. Thereby, it was possible to broadcast that breast cancer is a very complex disease, and that distinct mechanisms are activated depending on specific clinicopathological characteristics. As far as we know, there are still no studies reporting the use of proteomics-based strategies to assess the impact of chronic pesticide exposure in women with breast cancer. To fill this gap, the present study proposes a toxicoproteomics perspective to investigate the systemic profile of differentially expressed proteins in the blood of breast cancer patients chronically exposed to pesticides, by using a high-throughput label-free proteomic strategy, and provide an integrative clinicopathological view based on bioinformatics approaches and validation experiments.
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_00:07:27.904.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joseph Evaristo
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-15 03:48:11	ID requested
⏵ 1	2021-09-09 00:07:28	announced

Pizzatti L, Kawassaki ACB, Fadel B, Nogueira FCS, Evaristo JAM, Woldmar N, Teixeira GT, Da Silva JC, Scandolara TB, Rech D, Candiotto LPZ, Silveira GF, Pavanelli WR, Panis C, and Estrogen Receptor Pathways in Breast Cancer Women Chronically Exposed. Front Oncol, 10():1698(2020) [pubmed]

submitter keyword: Toxicoproteomic, LCMS, pesticide exposure, breast cancer,

Fabio C.S. Nogueira
contact affiliation	Laboratory of Proteomics/LADETEC, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
contact email	fabiocsn@gmail.com
lab head
Joseph Evaristo
contact affiliation	Laboratório de Proteômica - LABPROT, Instituto de Química, Universidade Federal do Rio de Janeiro
contact email	joseph.am.evaristo@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD018577

PRIDE project URI

• PRIDE
  1. PXD018577
     1. Label: PRIDE project
     2. Name: Toxicoproteomic-based screening discloses pivotal downregulated mechanisms triggered by chronic pesticide exposure in breast cancer patients.