PXD018560
PXD018560 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | An atlas of O-glycans on peptide hormones reveal wide biological roles |
| Description | Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we executed a focused discovery strategy to provide an extensive map of O-glycans on peptides hormones. We found that almost one third of the 279 classified peptide hormones carry O-glycans. Many of the identified O-glycosites were conserved and are predicted to serve roles in proprotein processing, receptor interaction, biodistribution and biostability. We demonstrate that O-glycans positioned within the receptor binding motifs of members of the NPY and Glucagon families modulate receptor activation properties and substantially extend peptide half-lives. Our study highlights the importance of O-glycosylation in the biology of peptide hormones, and our map of O-glycosites in this large class of biomolecules serves as a discovery platform for this important class of molecules with potential opportunities for new drug designs. |
| HostingRepository | MassIVE |
| AnnounceDate | 2020-06-24 |
| AnnouncementXML | Submission_2020-06-24_15:04:45.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Thomas Daugbjerg Madsen |
| SpeciesList | scientific name: Sus scrofa; common name: pig; NCBI TaxID: 9823; scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; scientific name: Rattus norvegicus; common name: Norway rat; NCBI TaxID: 10116; scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | HexNAc; Hex(1)HexNAc(1); Carbamidomethyl; Oxidation; TMT6plex |
| Instrument | LTQ Orbitrap Velos; Orbitrap Fusion ETD |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-04-15 00:47:58 | ID requested | |
| ⏵ 1 | 2020-06-24 15:04:45 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Peptide stability, Glycosylation, Metabolism, GLP-1, Secretin, PYY |
Contact List
| Katrine Schjoldager | |
|---|---|
| contact affiliation | University of Copenhagen, Institute of Cellular and Molecular Medicine, Copenhagen Center for Glycomics |
| contact email | Schjoldager@sund.ku.dk |
| lab head | |
| Thomas Daugbjerg Madsen | |
| contact affiliation | University of Copenhagen |
| contact email | Daugbjerg@sund.ku.dk |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085289/ |
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