PXD018539

PXD018539 is an original dataset announced via ProteomeXchange.

Title	LC-MSMS of primary AML class I immunopeptidome (mTECs+MPCs k-mer depletion approach)
Description	The development of therapeutic anticancer vaccines calls for the identification of tumor-specific antigens (TSAs). Though a combination of four cutting-edge proteogenomic approaches, we performed a deep exploration of the MHC-I presented peptides (MAPs) of 19 acute myeloid leukemia (AML) patients and identified various TSAs that could serve for the design of an anti-AML vaccine.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_10:17:41.207.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018539
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Courcelles Mathieu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Deamidated; Oxidation; monohydroxylated residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-14 05:47:00	ID requested
1	2021-03-18 23:14:43	announced
⏵ 2	2023-11-14 10:17:43	announced	2023-11-14: Updated project metadata.

10.6019/PXD018539;

Ehx G, Larouche JD, Durette C, Laverdure JP, Hesnard L, Vincent K, Hardy MP, Th, é, riault C, Rulleau C, Lanoix J, Bonneil E, Feghaly A, Apavaloaei A, Noronha N, Laumont CM, Delisle JS, Vago L, H, é, bert J, Sauvageau G, Lemieux S, Thibault P, Perreault C, Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes. Immunity, 54(4):737-752.e10(2021) [pubmed]

submitter keyword: AML, LC-MSMS, immunopeptidome, MHC class I

Pierre Thibault
contact affiliation	Institute for Research in Immunology and Cancer, Department of Biochemistry, Department of Chemistry, Université de Montréal, Québec, Canada H3T 1J4
contact email	pierre.thibault@umontreal.ca
lab head
Courcelles Mathieu
contact affiliation	IRIC
contact email	mathieu.courcelles@umontreal.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD018539

PRIDE project URI

• PRIDE
  1. PXD018539
     1. Label: PRIDE project
     2. Name: LC-MSMS of primary AML class I immunopeptidome (mTECs+MPCs k-mer depletion approach)