PXD018459 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | The viral vectored vaccine targeting Thymosin β10 controls tumour growth in a murine model of prostate cancer |
| Description | In the current study, we used immunopeptidomics to analyse the murine prostate cancer peptidome for the development of next generation prostate cancer vaccines using the TRansgenic Adenocarcinoma of Mouse Prostate, TRAMP, model. We have performed immunopeptidomic analysis of the normal mouse prostate and mouse prostate adenocarcinoma samples and identified a number of peptides overexpressed on tumour tissue compared to the normal prostate. We selected two of these proteins previously reported to play a role in carcinogenesis, thymosin beta 4 (Thyβ4) and thymosin beta 10 (Thyβ10), expressed them in the chimpanzee adenovirus (ChAdOx1) and Modified Vaccinia Ankara (MVA) recombinant viral vectors and evaluated these constructs as a candidate prostate cancer vaccine in a murine prostate cancer model. We have found that the vaccine encoding the Thyβ10 polypeptide tethered to the MHC class II associated invariant chain, CD74, significantly delayed outgrowth of established tumours in an ectopic TRAMP-C1 mouse model of prostate cancer. The observed tumour-protective efficacy was not associated with Thyβ10-specific cellular or antibody responses, suggesting an existence of other mechanisms underlying anti-tumour effect in this model that are yet to be elucidated. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-28 |
| AnnouncementXML | Submission_2026-05-28_08:59:44.290.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD018459 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Nicola Ternette |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | Ethyl; Amidated; Hex; Oxidation; Phosphopropargyl; Propionamide; Phospho; PEITC; Cation:Na; Deamidated; Trp->Kynurenin; Acetyl; Sulfo; Cation:K; Formyl; Carbamyl; LG-anhydrolactam; Cysteinyl; Gln->pyro-Glu; Trioxidation; Glu->pyro-Glu; Dehydrated; Biotin; Dioxidation; NA-OA-NO2; dHex; glycidamide |
| Instrument | TripleTOF 5600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2020-04-10 13:34:31 | ID requested | |
| ⏵ 1 | 2026-05-28 08:59:44 | announced | |
Publication List
Keyword List
| ProteomeXchange project tag: Human Immuno-Peptidome Project (HUPO-HIPP) (B/D-HPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project |
| submitter keyword: Immunopeptidomics, murine MHC, Prostate Cancer |
Contact List
| Nicola Ternette |
|---|
| contact affiliation | University of Oxford |
| contact email | nicola.ternette@ndm.ox.ac.uk |
| lab head | |
| Nicola Ternette |
|---|
| contact affiliation | University of Oxford |
| contact email | nicola.ternette@ndm.ox.ac.uk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018459
- Label: PRIDE project
- Name: The viral vectored vaccine targeting Thymosin β10 controls tumour growth in a murine model of prostate cancer
