PXD018458

PXD018458 is an original dataset announced via ProteomeXchange.

Title	Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells
Description	m6A is the most abundant modification of mRNA in mammals and plays an important role in human development and disease. METTL14 is a key component of m6A methyltransferase complex. The project showed that its post-translational arginine methylation can regulate the generation of m6A and the endoderm differentiation of mouse embryonic stem cells, indicating its essential function in the normal development of embryos.
HostingRepository	iProX
AnnounceDate	2021-05-17
AnnouncementXML	Submission_2023-03-01_18:27:58.291.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xiaona Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	monomethylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-10 00:32:45	ID requested
1	2021-05-16 20:48:24	announced
⏵ 2	2023-03-01 18:28:01	announced	2023-03-02: Update publication information.

Liu X, Wang H, Zhao X, Luo Q, Wang Q, Tan K, Wang Z, Jiang J, Cui J, Du E, Xia L, Du W, Chen D, Xia L, Xiao S, -methyladenosine modification and endoderm differentiation of mouse embryonic stem cells. Nat Commun, 12(1):3780(2021) [pubmed]

submitter keyword: METTL14, arginine methylation, m6A, endoderm differentiation

Shan Xiao
contact affiliation	Southern Medical University
contact email	asdfg@smu.edu.cn
lab head
Xiaona Liu
contact affiliation	Southern Medical University
contact email	liuxn0406@163.com
dataset submitter

iProX dataset URI