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PXD018449

PXD018449 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitlePhosphoproteomic analysis of signaling downstream of p85β
Descriptionp85β is a regulatory subunit of phosphatidylinositol 3-kinase. The signaling mechanism of p85β is poorly understood. Quantitative mass spectrometry-based phosphoproteomic analysis was therefore performed to reveal proteins with an altered phosphorylation status upon PIK3R2 depletion in ovarian cancer cell line SKOV3. This profiling yielded 90 unique altered phosphopeptides, mapping to 29 and 45 proteins whose levels were downregulated or upregulated at P<0.05 by PIK3R2-specific siRNA, respectively. We observed significant enrichment of proteins in ubiquitin-mediated proteolysis and autophagy regulation, suggesting a role of p85β in regulating these cellular processes.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:03:23.463.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLydia Cheung
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-04-09 07:28:05ID requested
12020-05-08 03:59:28announced
22020-05-12 22:18:02announced2020-05-13: Updated publication reference for PubMed record(s): 32385243.
32024-10-22 05:03:24announced2024-10-22: Updated project metadata.
Publication List
Rao L, Mak VCY, Zhou Y, Zhang D, Li X, Fung CCY, Sharma R, Gu C, Lu Y, Tipoe GL, Cheung ANY, Mills GB, Cheung LWT, regulates autophagic degradation of AXL to activate oncogenic signaling. Nat Commun, 11(1):2291(2020) [pubmed]
10.1038/s41467-020-16061-7;
Keyword List
submitter keyword: Phosphoproteomics, PI3K, p85
Contact List
Dr CHEUNG, Lydia Wai Ting
contact affiliationAssistant Professor, School of Biomedical Sciences, Faculty of Medicine, The University of Hong Kong, HK SAR
contact emaillydiacwt@hku.hk
lab head
Lydia Cheung
contact affiliationUniversity of Hong Kong
contact emaillydiacwt@hku.hk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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