PXD018344

PXD018344 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of auto mono-ADP-ribosylation sites on SIRT6 and SIRT7
Description	The aim of this project was to identify the auto mono-ADP-ribosylation sites on SIRT6 and SIRT7 to study the effect of the point mutations S56A and N189A respectively on their ADP-ribosylation activity. In addition, the mono-ADP-ribosylation pattern of SIRT7 was obtained in cells under different stress conditions (UV, H2O2, ionizing Irradiation and glucose starvation).
HostingRepository	PRIDE
AnnounceDate	2021-04-20
AnnouncementXML	Submission_2021-04-19_21:34:31.450.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Joan Josep Bech-Serra
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	adenosine diphosphoribosyl (ADP-ribosyl) modified residue; phosphorylated residue; acetylated residue
Instrument	Orbitrap Eclipse; Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-03 00:15:38	ID requested
1	2021-04-19 08:04:35	announced
⏵ 2	2021-04-19 21:34:32	announced	2021-04-20: Updated project metadata.

Publication List

10.1126/SCIADV.AAZ2590;
Simonet NG, Thackray JK, Vazquez BN, Ianni A, Espinosa-Alcantud M, Morales-Sanfrutos J, Hurtado-Bag, è, s S, Sabid, ó E, Buschbeck M, Tischfield J, De La Torre C, Esteller M, Braun T, Olivella M, Serrano L, Vaquero A, SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1. Sci Adv, 6(30):eaaz2590(2020) [pubmed]

10.1126/SCIADV.AAZ2590;

Simonet NG, Thackray JK, Vazquez BN, Ianni A, Espinosa-Alcantud M, Morales-Sanfrutos J, Hurtado-Bag, è, s S, Sabid, ó E, Buschbeck M, Tischfield J, De La Torre C, Esteller M, Braun T, Olivella M, Serrano L, Vaquero A, SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1. Sci Adv, 6(30):eaaz2590(2020) [pubmed]

Keyword List

submitter keyword: sirtuins
SirT7
ADP-ribosylation
macroH2A
glucose starvation
chromatin
calorie restriction
aging
Orbitrap Lumos
Orbitrap Eclipse

submitter keyword: sirtuins

SirT7

ADP-ribosylation

macroH2A

glucose starvation

chromatin

calorie restriction

aging

Orbitrap Lumos

Orbitrap Eclipse

Contact List

Alex Vaquero
contact affiliation	Chromatin Biology Laboratory Josep Carreras Leukaemia Research Institute (IJC) Ctra de Can Ruti, Camí de les Escoles s/n 08916, Badalona, Barcelona, Spain
contact email	avaquero@carrerasresearch.org
lab head
Joan Josep Bech-Serra
contact affiliation	Proteomics Unit - Josep Carreras Leukaemia Research Institute
contact email	jbech@carrerasresearch.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD018344
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD018344

PRIDE project URI

Repository Record List

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