PXD018314

PXD018314 is an original dataset announced via ProteomeXchange.

Title	Proteome analysis of human visceral and subcutaneous adipocytes identifies altered metabolic control points
Description	Adipose tissue is a primary regulator of energy balance and metabolism. The distribution of adipose tissue depots is of clinical interest because the accumulation of upper-body subcutaneous (ASAT) and visceral adipose tissue (VAT) is associated with cardiometabolic diseases, whereas lower-body gluteal-femoral adipose tissue (GFAT) appears to be protective. There is heterogeneity in the morphological and metabolic traits of adipocytes obtained from different regions of the body, but detailed knowledge of the constituent proteins in each depot is lacking. Here, we determined the human adipocyte proteome from ASAT, VAT and GFAT using high-resolution SWATH mass spectrometry proteomics.
HostingRepository	PRIDE
AnnounceDate	2021-04-20
AnnouncementXML	Submission_2021-04-19_21:31:55.998.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Christoph Krisp
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-01 02:47:44	ID requested
1	2021-04-19 07:17:07	announced
⏵ 2	2021-04-19 21:31:56	announced	2021-04-20: Updated project metadata.

10.1152/AJPENDO.00473.2020;

Raajendiran A, Krisp C, Souza DP, Ooi G, Burton PR, Taylor RA, Molloy MP, Watt MJ, Proteome analysis of human adipocytes identifies depot-specific heterogeneity at metabolic control points. Am J Physiol Endocrinol Metab, 320(6):E1068-E1084(2021) [pubmed]

submitter keyword: lipid metabolism,proteomics, SWATHßMS, adipose tissue,obesity

Matthew Watt
contact affiliation	Department of Physiology School of Biomedical Sciences Faculty of Medicine Dentistry and Health Sciences The University of Melbourne, Victoria 3010 Australia
contact email	matt.watt@unimelb.edu.au
lab head
Christoph Krisp
contact affiliation	University Medical Center Hamburg-Eppendorf Institute of Clinical Chemistry and Laboratory Medicine Mass Spectrometric Proteomics
contact email	c.krisp@uke.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/04/PXD018314

PRIDE project URI

• PRIDE
  1. PXD018314
     1. Label: PRIDE project
     2. Name: Proteome analysis of human visceral and subcutaneous adipocytes identifies altered metabolic control points