PXD018311

PXD018311 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Mouse mitochondrial proteome in the kidney and the brain
Description	Hydroxybenzoic acids derivatives (HBAs) are natural phenolic compounds that are being used for the experimental treatment of primary CoQ deficiency. Some of these compounds are also able to reduce the animals body weight. However, the mechanisms of these therapeutic effects remain obscure. In this study, we used an analysis of the mitochondrial proteome to evaluate the effect of a high dose of-resorcylic acid (-RA), an HBA potentially useful for the treatment of Coenzyme Q (CoQ) deficiencies, in wild-type animals. The results highlight novel molecular mechanisms of HBAs and provide a translational perspective for the use the -RA in the treatment of CoQ deficiencies, overweight and obesity.
HostingRepository	PRIDE
AnnounceDate	2023-05-14
AnnouncementXML	Submission_2023-05-14_14:14:59.901.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	AgustínHidalgo Gutiérrez
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-01 00:51:58	ID requested
1	2021-11-03 06:03:51	announced
⏵ 2	2023-05-14 14:15:00	announced	2023-05-14: Updated project metadata.

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

ProteomeXchange project tag: EPIC-XS
submitter keyword: 2, β-resorcylic acid,Brain
kidney
mitochondria,4-dihydroxybenzoic acid
C57BL/6

ProteomeXchange project tag: EPIC-XS

submitter keyword: 2, β-resorcylic acid,Brain

kidney

mitochondria,4-dihydroxybenzoic acid

C57BL/6

Contact List

Luis Carlos LópezGarcía
contact affiliation	University of Granada
contact email	Luisca@ugr.es
lab head
AgustínHidalgo Gutiérrez
contact affiliation	University of Granada
contact email	Ahg@ugr.es
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD018311
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD018311

PRIDE project URI

Repository Record List

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