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PXD018311

PXD018311 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMouse mitochondrial proteome in the kidney and the brain
DescriptionHydroxybenzoic acids derivatives (HBAs) are natural phenolic compounds that are being used for the experimental treatment of primary CoQ deficiency. Some of these compounds are also able to reduce the animals body weight. However, the mechanisms of these therapeutic effects remain obscure. In this study, we used an analysis of the mitochondrial proteome to evaluate the effect of a high dose of-resorcylic acid (-RA), an HBA potentially useful for the treatment of Coenzyme Q (CoQ) deficiencies, in wild-type animals. The results highlight novel molecular mechanisms of HBAs and provide a translational perspective for the use the -RA in the treatment of CoQ deficiencies, overweight and obesity.
HostingRepositoryPRIDE
AnnounceDate2023-05-14
AnnouncementXMLSubmission_2023-05-14_14:14:59.901.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAgustínHidalgo Gutiérrez
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-04-01 00:51:58ID requested
12021-11-03 06:03:51announced
22023-05-14 14:15:00announced2023-05-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: EPIC-XS
submitter keyword: 2, β-resorcylic acid,Brain
kidney
mitochondria,4-dihydroxybenzoic acid
C57BL/6
Contact List
Luis Carlos LópezGarcía
contact affiliationUniversity of Granada
contact emailLuisca@ugr.es
lab head
AgustínHidalgo Gutiérrez
contact affiliationUniversity of Granada
contact emailAhg@ugr.es
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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