PXD018293

PXD018293 is an original dataset announced via ProteomeXchange.

Title	Phospho-proteomics enables classification of cancer subtypes and nomination of druggable kinases for individual patients of diffuse-type gastric cancer
Description	The diffuse-type gastric cancer (DGC) constitutes a subgroup of gastric cancer with poor prognosis and no effective molecular therapies. Here, we report a phosphoproteomic landscape of DGC derived from 83 tumors together with their nearby tissues. Based on phosphorylation, DGC could be classified into three molecular subtypes with distinct overall survival (OS) and chemosensitivity. We identified 16 kinases whose activities were associated with poor OS. These activated kinases covered several cancer hallmark pathways, with the MTOR signaling network being the most frequently activated. We proposed a patient-specific strategy based on the hierarchy of clinically actionable kinases for prioritization of kinases for further clinical evaluation. Our global data analysis indicates that in addition to finding activated kinase pathways in DGC, large-scale phosphoproteomics could be used to classify DGCs into subtypes that are associated with distinct clinical outcomes as well as nomination of kinase targets that may be inhibited for cancer treatments.
HostingRepository	iProX
AnnounceDate	2020-03-31
AnnouncementXML	Submission_2020-03-30_21:06:25.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mengsha Tong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-30 21:04:27	ID requested
⏵ 1	2020-03-30 21:06:26	announced

Tong M, Yu C, Shi J, Huang W, Ge S, Liu M, Song L, Zhan D, Xia X, Liu W, Feng J, Shi W, Ji J, Gao J, Shi T, Zhu W, Ding C, Wang Y, He F, Shen L, Li T, Qin J, Phosphoproteomics Enables Molecular Subtyping and Nomination of Kinase Candidates for Individual Patients of Diffuse-Type Gastric Cancer. iScience, 22():44-57(2019) [pubmed]

submitter keyword: Diffuse-type Gastric cancer

Phosphoproteomics

Jun Qin
contact affiliation	National Center for Protein Sciences (The PHOENIX Center, Beijing)
contact email	jqin@bcm.edu
lab head
Mengsha Tong
contact affiliation	National Center for Protein Sciences (The PHOENIX Center, Beijing)
contact email	mstong91@163.com
dataset submitter

iProX dataset URI