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PXD018291

PXD018291 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA decision tree searching strategy to boost the identification of cross-linked peptides
DescriptionWe describe an efficient decision tree searching strategy (DTSS) to boost the identification of cross-linked peptides. The DTSS approach allows the identification of a wealth of complementary information to facilitate the construction of more protein-protein interaction networks for human cell lysate, which was tested by the use of a recently reported cross-linking dataset (ACS Cent. Sci. 2019, 5, 1514−1522). A variant of the PhoX-linker, named pDSPE was synthesized and applied to cross-link E.coli cell lysate to demonstrate that the acquisition of doubly charged ions can significantly improve identifica-tion results. The method can be seamlessly integrated to other search engines to maximize the number of identified cross-links
HostingRepositoryPRIDE
AnnounceDate2024-10-08
AnnouncementXMLSubmission_2024-10-08_11:15:32.731.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD018291
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterWenzhang Chen
SpeciesList scientific name: Escherichia coli; NCBI TaxID: 562;
ModificationListBiotin:Sigma-B1267; Carbamidomethyl
InstrumentOrbitrap Fusion ETD
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-03-30 15:31:26ID requested
12024-10-08 11:15:42announced
Publication List
10.1021/acs.analchem.0c00452;
Huang R, Gao X, Xu Z, Zhu W, Wei D, Jiang B, Chen H, Chen W, Decision Tree Searching Strategy to Boost the Identification of Cross-Linked Peptides. Anal Chem, 92(20):13702-13710(2020) [pubmed]
10.6019/PXD018291;
Keyword List
submitter keyword: XLINK-MS, data-analysis
Contact List
wenzhang chen
contact affiliationSIAIS, ShanghaiTech University
contact emailchenwzh1@shanghaitech.edu.cn
lab head
Wenzhang Chen
contact affiliationShanghaitech University
contact emailchenwzh1@shanghaitech.edu.cn
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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