PXD018270

PXD018270 is an original dataset announced via ProteomeXchange.

Title	Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis via SYK activation
Description	Identification of covalently bound protein targets of probe WEL028 in wild-type or mutant HL-60 cells.
HostingRepository	PRIDE
AnnounceDate	2020-05-25
AnnouncementXML	Submission_2020-08-11_04:19:25.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tom van der Wel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-30 06:54:16	ID requested
1	2020-05-25 07:47:44	announced
⏵ 2	2020-08-11 04:19:26	announced	2020-08-11: Updated publication reference for PubMed record(s): 32587248.

van der Wel T, Hilhorst R, den Dulk H, van den Hooven T, Prins NM, Wijnakker JAPM, Florea BI, Lenselink EB, van Westen GJP, Ruijtenbeek R, Overkleeft HS, Kaptein A, Barf T, van der Stelt M, Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis. Nat Commun, 11(1):3216(2020) [pubmed]

submitter keyword: Target engagement, target validation, kinase, inhibitor, probe, chemical genetics, chemical biology

Mario van der Stelt
contact affiliation	Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University
contact email	m.van.der.stelt@chem.leidenuniv.nl
lab head
Tom van der Wel
contact affiliation	Leiden Institute of Chemistry, Leiden University
contact email	t.van.der.wel@lic.leidenuniv.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD018270

PRIDE project URI

• PRIDE
  1. PXD018270
     1. Label: PRIDE project
     2. Name: Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis via SYK activation