PXD018230 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Functional states in tumor-initiating cell differentiation in human colorectal cancer |
Description | Intra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell mRNA-sequencing (scRNA-seq) of patient-derived CRC models to decipher distinct cell subpopulations based on their transcriptional profiles. Cell type-specific expression modules of stem-like, transit amplifying-like, and differentiated CRC cells resemble differentiation states of normal intestinal epithelial cells. Strikingly, identified subpopulations differ in proliferative activity and metabolic state. In summary, we here show at single-cell resolution that transcriptional heterogeneity identifies functional states during TIC differentiation. Targeting transcriptional states associated to cancer cell differentiation might unravel vulnerabilities in human CRC. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:21:51.177.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Torsten Mueller |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-03-27 02:53:17 | ID requested | |
1 | 2021-05-07 02:54:52 | announced | |
2 | 2021-05-09 22:18:49 | announced | 2021-05-10: Updated project metadata. |
⏵ 3 | 2024-10-22 05:21:59 | announced | 2024-10-22: Updated project metadata. |
Publication List
Zowada MK, Tirier SM, Dieter SM, Krieger TG, Oberlack A, Chua RL, Huerta M, Ten FW, Laaber K, Park J, Jechow K, M, ΓΌ, ller T, Kalxdorf M, Kriegsmann M, Kriegsmann K, Herbst F, Krijgsveld J, Schneider M, Eils R, Glimm H, Conrad C, Ball CR, Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer. Cancers (Basel), 13(5):(2021) [pubmed] |
10.3390/cancers13051097; |
Keyword List
submitter keyword: tumor heterogeneity, transcriptional programs,colorectal cancer, tumor cell differentiation, patient-derived cancer models, tumor-initiating cells, tumor metabolism, single-cell RNA-sequencing |
Contact List
Claudia R. Ball |
contact affiliation | NCT Dresden |
contact email | claudia.ball@nct-dresden.de |
lab head | |
Torsten Mueller |
contact affiliation | DKFZ |
contact email | torsten.mueller84@googlemail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018230
- Label: PRIDE project
- Name: Functional states in tumor-initiating cell differentiation in human colorectal cancer