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PXD018230

PXD018230 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleFunctional states in tumor-initiating cell differentiation in human colorectal cancer
DescriptionIntra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell mRNA-sequencing (scRNA-seq) of patient-derived CRC models to decipher distinct cell subpopulations based on their transcriptional profiles. Cell type-specific expression modules of stem-like, transit amplifying-like, and differentiated CRC cells resemble differentiation states of normal intestinal epithelial cells. Strikingly, identified subpopulations differ in proliferative activity and metabolic state. In summary, we here show at single-cell resolution that transcriptional heterogeneity identifies functional states during TIC differentiation. Targeting transcriptional states associated to cancer cell differentiation might unravel vulnerabilities in human CRC.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:21:51.177.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTorsten Mueller
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-03-27 02:53:17ID requested
12021-05-07 02:54:52announced
22021-05-09 22:18:49announced2021-05-10: Updated project metadata.
32024-10-22 05:21:59announced2024-10-22: Updated project metadata.
Publication List
Zowada MK, Tirier SM, Dieter SM, Krieger TG, Oberlack A, Chua RL, Huerta M, Ten FW, Laaber K, Park J, Jechow K, M, ΓΌ, ller T, Kalxdorf M, Kriegsmann M, Kriegsmann K, Herbst F, Krijgsveld J, Schneider M, Eils R, Glimm H, Conrad C, Ball CR, Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer. Cancers (Basel), 13(5):(2021) [pubmed]
10.3390/cancers13051097;
Keyword List
submitter keyword: tumor heterogeneity, transcriptional programs,colorectal cancer, tumor cell differentiation, patient-derived cancer models, tumor-initiating cells, tumor metabolism, single-cell RNA-sequencing
Contact List
Claudia R. Ball
contact affiliationNCT Dresden
contact emailclaudia.ball@nct-dresden.de
lab head
Torsten Mueller
contact affiliationDKFZ
contact emailtorsten.mueller84@googlemail.com
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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