PXD018224

PXD018224 is an original dataset announced via ProteomeXchange.

Title	Multi-Omics’ Defines Unstable and Stable Atherosclerotic Plaque Signatures and Identifies Novel Targets for Plaque Stabilisation
Description	The rupture of unstable atherosclerotic plaques, leading to debilitating or fatal thrombotic events, are a major health concern worldwide. Limited understanding as to the molecular drivers of plaque destabilisation and rupture hinders efforts in diagnosis and treatment prior to thrombotic events. Using an advanced pre-clinical model (tandem stenosis), we characterise the molecular signatures associated with plaque instability in atherosclerotic vessels.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_09:04:10.329.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	david greening
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-26 23:09:08	ID requested
1	2023-07-23 19:50:31	announced
⏵ 2	2023-11-14 09:04:18	announced	2023-11-14: Updated project metadata.

Chen YC, Smith M, Ying YL, Makridakis M, Noonan J, Kanellakis P, Rai A, Salim A, Murphy A, Bobik A, Vlahou A, Greening DW, Peter K, Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization. Commun Biol, 6(1):265(2023) [pubmed]

submitter keyword: Atherosclerosis,Mouse, plaque, thrombosis

David Greening
contact affiliation	Molecular Proteomics, Baker Heart Inst., Australia
contact email	david.greening@baker.edu.au
lab head
david greening
contact affiliation	Baker Heart and Diabetes Inst.
contact email	david.greening@baker.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD018224

PRIDE project URI

• PRIDE
  1. PXD018224
     1. Label: PRIDE project
     2. Name: Multi-Omics’ Defines Unstable and Stable Atherosclerotic Plaque Signatures and Identifies Novel Targets for Plaque Stabilisation