PXD018205
PXD018205 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Restriction of essential amino acids dictates the systemic response to dietary protein dilution |
Description | Dietary protein dilution (DPD) promotes metabolic remodelling and health but the precise nutritional components driving this response remain elusive. Here we demonstrate that dietary amino acids (AA) are sufficient and necessary to drive the response to DPD. In particular, the restriction of dietary essential AA (EAA) supply, but not non-EAA, drives the systemic metabolic response to total AA deprivation. Furthermore, systemic deprivation of Thr and Trp, independent of total AA supply, are both adequate and necessary to confer the systemic metabolic response to both diet, and genetic AA-transport loss, driven AA restriction. Thr is also potentially limiting in low-protein diet fed humans, and dietary Thr restriction (DTR) retarded the development of obesity-associated metabolic dysfunction in mice. Liver-derived fibroblast growth factor 21 was required for the metabolic remodelling with DTR. Strikingly, hepatocyte-selective establishment of Thr biosynthetic capacity reversed the systemic response to DTR. Taken together, our studies demonstrate that the restriction of EAA are sufficient and necessary to confer the systemic metabolic effects of DPD. |
HostingRepository | PRIDE |
AnnounceDate | 2020-06-15 |
AnnouncementXML | Submission_2020-06-15_02:59:15.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Cheng Huang |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-03-25 23:52:24 | ID requested | |
⏵ 1 | 2020-06-15 02:59:16 | announced |
Publication List
Yap YW, Rusu PM, Chan AY, Fam BC, Jungmann A, Solon-Biet SM, Barlow CK, Creek DJ, Huang C, Schittenhelm RB, Morgan B, Schmoll D, Kiens B, Piper MDW, Heikenw, ä, lder M, Simpson SJ, Br, ö, er S, Andrikopoulos S, M, ü, ller OJ, Rose AJ, Restriction of essential amino acids dictates the systemic metabolic response to dietary protein dilution. Nat Commun, 11(1):2894(2020) [pubmed] |
Keyword List
submitter keyword: essential amino acids, Thr biosynthetic |
Contact List
Adam Rose | |
---|---|
contact affiliation | 1 Department of Biochemistry and Molecular Biology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton 3800, Australia. |
contact email | adam.rose@monash.edu |
lab head | |
Cheng Huang | |
contact affiliation | Monash University |
contact email | cheng.huang@monash.edu |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD018205 |
PRIDE project URI |
Repository Record List
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