PXD018112 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The Aspergillus fumigatus secretome alters the proteome of Pseudomonas aeruginosa to stimulate bacterial growth: implications for co-infection |
Description | Individuals with cystic fibrosis are susceptible to co-infection by Aspergillus fumigatus and Pseudomonas aeruginosa, however P. aeruginosa eventually predominates as the primary pathogen. Several factors are likely to facilitate P. aeruginosa colonization in the airways, including alterations to the microbial environment. In this study, significant growth proliferation was observed in P. aeruginosa when the bacteria were exposed to culture filtrates produced by A. fumigatus in a nitrate-rich, nutrient-poor liquid broth, Czapek-Dox. Proteomic analysis of the A. fumigatus culture filtrate identified a significant number of environment-altering proteases and peptidases, which may contribute to the growth promoting effect observed when P. aeruginosa is exposed to this culture filtrate. These findings offer insights into the determinants that contribute to P. aeruginosa proliferation in the presence of A. fumigatus. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:09:35.997.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | James Carolan |
SpeciesList | scientific name: Aspergillus fumigatus Af293; NCBI TaxID: 330879; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-03-19 16:12:58 | ID requested | |
1 | 2020-07-22 01:46:32 | announced | |
⏵ 2 | 2024-10-22 05:09:36 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1074/mcp.ra120.002059; |
Margalit A, Carolan JC, Sheehan D, Kavanagh K, to Stimulate Bacterial Growth: Implications for Co-infection. Mol Cell Proteomics, 19(8):1346-1359(2020) [pubmed] |
Keyword List
submitter keyword: shotgun proteomics, LC-MS, culture filtrate,Aspergillus fumigatus |
Contact List
Jim Carolan |
contact affiliation | Applied Proteomics Lab, Department of Biology, Maynooth University, Co. Kildare, Ireland |
contact email | james.c.carolan@gmail.com |
lab head | |
James Carolan |
contact affiliation | Biology |
contact email | james.carolan@nuim.ie |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD018112 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018112
- Label: PRIDE project
- Name: The Aspergillus fumigatus secretome alters the proteome of Pseudomonas aeruginosa to stimulate bacterial growth: implications for co-infection