PXD018102

PXD018102 is an original dataset announced via ProteomeXchange.

Title	The quantitative and phosphorylation proteomics analysis of mouse liver after tick-borne Babesia microti infection
Description	Babesia microti is a tick-borne protozoan parasite that infects the red blood cells of mice, humans, and other mammals. Hosts infected with B. microti exhibit a series of clinical symptoms, including fever, anaemia, and haemoglobinuria, and multiple-organ injury. The infection can even result in death in patients with severe symptoms. Here, after BALB/c mice were infected with B. microti, liver tissues had serious injury and obvious swelling, cells were deformed, lipid droplets had formed in the cytoplasm, and organelles such as mitochondria also exhibited morphological changes. To further investigate the molecular mechanisms underlying liver injury and liver self-repair after B. microti infection, data-independent acquisition quantitative (DIA) proteomics was used to analyse changes in the expression and phosphorylation of proteins in liver tissues in the infection period and recovery period after BALB/c mice were infected with B. microti. The pattern of changes and the functions of proteins in lipid metabolism, growth and development, and immunity during liver injury and repair were investigated.
HostingRepository	iProX
AnnounceDate	2020-03-19
AnnouncementXML	Submission_2023-08-27_20:58:53.812.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Minjing Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-18 21:52:46	ID requested
1	2020-03-18 21:58:03	announced
⏵ 2	2023-08-27 20:58:56	announced	2023-08-28: Update publication information.

Hu Y, Wang M, Ren S, Masoudi A, Xue X, Wang X, Yang X, Han Y, Li M, Wang H, Liu J, Quantitative proteomics and phosphoproteomic analyses of mouse livers after tick-borne Babesia microti infection. Int J Parasitol, 51(2-3):167-182(2021) [pubmed]

submitter keyword: Babesia microti, liver, phosphorylation, quantitative proteomics, lipid metabolism

Hui Wang
contact affiliation	Hebei Normal University
contact email	whui1981@163.com
lab head
Minjing Wang
contact affiliation	Hebei Normal University
contact email	1113950759@qq.com
dataset submitter

iProX dataset URI