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PXD018094
PXD018094 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics Characterization of COVID-19 lung tissues |
| Description | The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown. To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach, fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia. After virus inactivation, a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2 infected lung tissues. We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism, blood coagulation, immune response, angiogenesis, and cell microenvironment regulation. Several inflammatory factors were up-regulated, which was possibly caused by the activation of NF-κB signaling. Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered. Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection, and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. |
| HostingRepository | iProX |
| AnnounceDate | 2020-03-19 |
| AnnouncementXML | Submission_2020-10-30_20:06:58.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ling Leng |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | iodoacetamide derivatized residue; monohydroxylated residue |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-03-18 10:14:39 | ID requested | |
| ⏵ 1 | 2020-10-30 20:06:59 | announced |
Publication List
Keyword List
| submitter keyword: proteomics, COVID-19 |
Contact List
| Wu Zhong | |
|---|---|
| contact affiliation | National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology. |
| contact email | zhongwu@bmi.ac.cn |
| lab head | |
| Ling Leng | |
| contact affiliation | Department of Medical Science Research Center, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences |
| contact email | zhenlinger@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
