PXD018077

PXD018077 is an original dataset announced via ProteomeXchange.

Title	ChIP-MS of Glucocorticoid Receptor in primary mouse macrophages
Description	Glucocorticoids (GCs) are the most effective anti-inflammatory drugs in current clinical settings, yet their genomic modes of action are poorly understood. GCs bind to the Glucocorticoid Receptor (GR), which acts as a transcription factor to control gene expression in the immune system. Understanding the molecular mechanism that delineates gene repression of pro-inflammatory target genes from gene activation of metabolic genes will help to improve GC therapy and overcome adverse effects.
HostingRepository	PRIDE
AnnounceDate	2021-11-17
AnnouncementXML	Submission_2021-11-17_08:24:48.327.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Michael Wierer
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-17 03:11:08	ID requested
⏵ 1	2021-11-17 08:24:49	announced

Greulich F, Wierer M, Mechtidou A, Gonzalez-Garcia O, Uhlenhaut NH, The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers. Cell Rep, 34(6):108742(2021) [pubmed]

submitter keyword: chromatin, epigenetics, transcription factor, immunology

Matthias Mann
contact affiliation	Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, Munich, Germany
contact email	mmann@biochem.mpg.de
lab head
Michael Wierer
contact affiliation	Department of Proteomics and Signal Transduction, Max-Planck Institute of Biochemistry, Martinsried, Germany
contact email	wierer@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD018077

PRIDE project URI

• PRIDE
  1. PXD018077
     1. Label: PRIDE project
     2. Name: ChIP-MS of Glucocorticoid Receptor in primary mouse macrophages