PXD018070

PXD018070 is an original dataset announced via ProteomeXchange.

Title	Transcriptome and proteome profiling of motor neuron model subjected to protein misfolding stress
Description	To identify molecular differences between closely related motor neurons relevant for understanding of neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), we exploited induced cranial and spinal motor neuron populations from mouse embryonic stem cells. We performed a large scale time-dependent TMT-based proteomics analysis in the presence and absence of protein misfolding stress. We profiled ~8,600 proteins from two different motor neuron cell lines, measured in two replicates and three time points.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:32:20.700.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shuvadeep Maity
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-17 01:42:23	ID requested
1	2024-03-06 04:41:12	announced
⏵ 2	2024-10-22 06:32:21	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: Motor Neuron, ALS, Stem cells, Proteomics

Christine Vogel
contact affiliation	Associate Professor, New York University - Department of Biology, Center for Genomics & Systems Biology
contact email	cvogel@nyu.edu
lab head
Shuvadeep Maity
contact affiliation	Assistant research Scientist
contact email	sm6622@nyu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/03/PXD018070

PRIDE project URI

• PRIDE
  1. PXD018070
     1. Label: PRIDE project
     2. Name: Transcriptome and proteome profiling of motor neuron model subjected to protein misfolding stress