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PXD018040

PXD018040 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentifying dynamic protein and RNA proximity interaction networks of actinin reveals RNA-binding and metabolic regulatory mechanisms
DescriptionWe deployed proximity-dependent biotinylation to identify actinin proximity proteins and RNA transcripts in human cardiomyocytes to reveal new functions of the actin cytoskeleton. We identified 285 proximity protein partners including unexpected effectors of RNA-binding and metabolism, and interrogated dynamic partners using a sarcomere assembly model.
HostingRepositoryPRIDE
AnnounceDate2022-02-15
AnnouncementXMLSubmission_2022-02-15_11:40:34.888.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterFeria Ladha
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListbiotinylated residue
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-03-13 02:48:27ID requested
12022-02-15 11:40:38announced
Publication List
Ladha FA, Thakar K, Pettinato AM, Legere N, Ghahremani S, Cohn R, Romano R, Meredith E, Chen YS, Hinson JT, Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2. Cell Rep, 36(6):109512(2021) [pubmed]
Keyword List
submitter keyword: Actinin, cardiomyocytes, quantitative proteomics
Contact List
J. Travis Hinson
contact affiliationThe Jackson Laboratory
contact emailtravis.hinson@jax.org
lab head
Feria Ladha
contact affiliationUniversity of Connecticut
contact emailferia.ladha@jax.org
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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