PXD018027 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Epitope shaving and fungal immune evasion – cell wall proteomes |
Description | The cell wall provides a major physical interface between fungal pathogens and their mammalian host. This extracellular armour is critical for fungal cell homeostasis and survival. Yet essential cell wall moieties, such as β-1,3-glucan, are recognised as pathogen-associated molecular patterns (PAMPs) that activate immune-mediated clearance mechanisms. We have reported that the opportunistic human fungal pathogen, Candida albicans, masks β-1,3-glucan following exposure to lactate, hypoxia or iron depletion. However, the precise mechanism(s) by which C. albicans masks β-1,3-glucan have remained obscure. Here, we performed proteomic analysis of cell walls from C. albicans cells grown in hypoxia or lactate compared to glucose-grown controls to identify mechanisms driving β-1,3-glucan masking. |
HostingRepository | PRIDE |
AnnounceDate | 2020-06-15 |
AnnouncementXML | Submission_2020-07-16_02:24:16.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | David Stead |
SpeciesList | scientific name: Candida albicans (Yeast); NCBI TaxID: 5476; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-03-12 08:20:51 | ID requested | |
1 | 2020-06-15 03:04:47 | announced | |
⏵ 2 | 2020-07-16 02:24:17 | announced | 2020-07-16: Updated publication reference for PubMed record(s): 32636248. |
Publication List
Childers DS, Avelar GM, Bain JM, Pradhan A, Larcombe DE, Netea MG, Erwig LP, Gow NAR, Brown AJP, Epitope Shaving Promotes Fungal Immune Evasion. mBio, 11(4):(2020) [pubmed] |
Keyword List
submitter keyword: Candida albicans, Cell wall, LC-MSMS |
Contact List
Professor Alistair J P Brown |
contact affiliation | MRC Centre for Medical Mycology University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK |
contact email | a.j.p.brown@exeter.ac.uk |
lab head | |
David Stead |
contact affiliation | University of Aberdeen |
contact email | d.stead@abdn.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018027
- Label: PRIDE project
- Name: Epitope shaving and fungal immune evasion – cell wall proteomes