PXD017979

PXD017979 is an original dataset announced via ProteomeXchange.

Title	Tauroursodeoxycholic acid-induced neural stem cell proliferation
Description	Tauroursodeoxycholic acid (TUDCA), an endogenous neuroprotective bile acid and a metabolic regulator, stimulates NSC proliferation and enhances adult NSC pool in vitro and in vivo. In this study, we dissected the mechanism triggered by this proliferation-inducing molecule, namely in mediating metabolic reprogramming. Liquid chromatography coupled with mass spectrometry based detection of differential proteomics revealed that TUDCA reduces the mitochondrial levels of the long-chain acyl-CoA dehydrogenase (LCAD), an enzyme crucial for β-oxidation of long-chain fatty acids (FA).
HostingRepository	PRIDE
AnnounceDate	2021-09-09
AnnouncementXML	Submission_2021-09-09_00:59:55.387.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ana Varela Coelho
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-10 09:20:25	ID requested
⏵ 1	2021-09-09 00:59:56	announced

Fernandes MB, Costa M, Ribeiro MF, Siquenique S, S, á, Santos S, Martins J, Coelho AV, Silva MFB, Rodrigues CMP, Sol, á S, Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation. Front Cell Dev Biol, 8():335(2020) [pubmed]

submitter keyword: Mouse, Neuronal stem cells, LC-MSMS

Ana Varela Coelho
contact affiliation	Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa - ITQB NOVA
contact email	varela@itqb.unl.pt
lab head
Ana Varela Coelho
contact affiliation	ITQB NOVA
contact email	varela@itqb.unl.pt
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD017979

PRIDE project URI

• PRIDE
  1. PXD017979
     1. Label: PRIDE project
     2. Name: Tauroursodeoxycholic acid-induced neural stem cell proliferation