PXD017968

PXD017968 is an original dataset announced via ProteomeXchange.

Title	Novel Functional Proteins Coded by the Human Genome Discovered in Metastases of Melanoma Patients
Description	In the advanced stages, malignant melanoma (MM) has a very poor prognosis. Due to tremendous efforts in cancer research, the overall survival of metastatic melanoma has doubled; however, complete eradication of the disease is almost unknown. With the advent of proteomics, deep-mining studies can reach low-abundant expression areas. The complexity of the proteome, however, still surpasses the dynamic range capabilities of current analytical techniques. Consequently, many predicted protein products with potential biological functions have not yet been verified in experimental proteomic data. This category of ‘missing proteins’ (MP) is comprised of all proteins that have been predicted but are currently unverified. As part of the initiative launched in 2016 in the United States, the European Cancer Moonshot Center has performed numerous deep proteomics analyses on samples from MM patients. In this study, nine MPs were clearly identified by mass spectrometry in MM metastases. Some MPs significantly-correlated with proteins that possess identical PFAM structural domains; and other MPs were significantly-associated with cancer-related proteins. This is the first study to our knowledge, where unknown and novel proteins have been annotated within metastasis, from Melanoma Cancer patients.
HostingRepository	PRIDE
AnnounceDate	2020-03-11
AnnouncementXML	Submission_2020-03-11_00:12:06.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD017968
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Aniel Sanchez
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex; Oxidation; monohydroxylated residue; Carbamidomethyl; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-10 04:14:09	ID requested
⏵ 1	2020-03-11 00:12:08	announced

Sanchez A, Kuras M, Murillo JR, Pla I, Pawlowski K, Szasz AM, Gil J, Nogueira FCS, Perez-Riverol Y, Eriksson J, Appelqvist R, Miliotis T, Kim Y, Baldetorp B, Ingvar C, Olsson H, Lundgren L, Ekedahl H, Horvatovich P, Sugihara Y, Welinder C, Wieslander E, Kwon HJ, Domont GB, Malm J, Rezeli M, Betancourt LH, Marko-Varga G, Novel functional proteins coded by the human genome discovered in metastases of melanoma patients. Cell Biol Toxicol, 36(3):261-272(2020) [pubmed]

submitter keyword: Metastases, Melanoma, Novel, Missing proteins

Gyorgy Marko-varga
contact affiliation	Principal investigator at Lund University
contact email	gyorgy.marko-varga@bme.lth.se
lab head
Aniel Sanchez
contact affiliation	Lund University
contact email	aniel.sanchez@med.lu.se
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD017968
     1. Label: PRIDE project
     2. Name: Novel Functional Proteins Coded by the Human Genome Discovered in Metastases of Melanoma Patients