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PXD017955

PXD017955 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic profiling of potential E6AP and HDAC6 targets in liver cancer cells
Description	E3 ubiquitin ligase E6AP and histone deacetylase HDAC6 play essential roles in the progress and development of various cancers. To explore the mechanism of E6AP and HDAC6 in liver cancer, we performed proteomic analysis with E6AP knockdown, HDAC6 knockdown and negative control HepG2 cells. We identified proteins were significantly regulated upon knockdown of E6AP or HDAC6. Pathway analysis confirmed the known phenotypic effect of E6AP and HDAC6. Overall, results from our investigation provide potential biological pathways and target genes controlled by E6AP and HDAC6 in liver cancer cells.
HostingRepository	iProX
AnnounceDate	2020-03-11
AnnouncementXML	Submission_2020-03-10_18:40:16.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lihua Ding
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-09 20:06:00	ID requested
1	2020-03-09 20:08:03	announced
⏵ 2	2020-03-10 18:40:17	announced	2020-03-11: Update datafiles

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: E6AP, HDAC6, liver cancer

Contact List

Qinong Ye
contact affiliation	Beijing Institute of Biotechnology
contact email	yeqn88@163.com
lab head
Lihua Ding
contact affiliation	Beijing Institute of Biotechnology
contact email	dinglh2004@126.com
dataset submitter

Full Dataset Link List

iProX dataset URI