PXD017936

PXD017936 is an original dataset announced via ProteomeXchange.

Title	Quantitative Proteomic and Phosphoproteomic Analyses of MLKL -/- mouse heart in response to influenza virus infection
Description	Influenza virus infection leads to global cardiac proteome remodeling during convalescence MTD project_description "Influenza virus infections lead to more than 500,000 hospitalizations in the U.S. every year. Patients with cardiovascular diseases have been shown to be at high risk of influenza mediated cardiac complications. Importantly, recent reports have provided clinical data supporting a direct link between laboratory-confirmed influenza virus infection and adverse cardiac events. However, the molecular mechanisms of how influenza virus infection induces detrimental cardiac changes, even after resolution of the pulmonary infection, is completely unknown. Mixed lineage kinase domain-like protein (MLKL) is a pseudokinas that mediates necroptosis. We performed global quantitative proteomics as well as phosphoproteomics to understand its role in the heart in response to inflenza virus infection in this study.
HostingRepository	PRIDE
AnnounceDate	2022-05-25
AnnouncementXML	Submission_2022-05-25_02:25:21.314.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yanbao Yu
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-09 03:52:09	ID requested
⏵ 1	2022-05-25 02:25:22	announced

Lin YH, Platt MP, Gilley RP, Brown D, Dube PH, Yu Y, Gonzalez-Juarbe N, Influenza Causes MLKL-Driven Cardiac Proteome Remodeling During Convalescence. Circ Res, 128(5):570-584(2021) [pubmed]

submitter keyword: Quantitative proteomics

phosphoproteomics

phosphorylation

Heart

MLKL

Norberto Gonzalez-Juarbe
contact affiliation	J. Craig Venter Institute 9605 Medical Center Dr. Rockville, MD 20850
contact email	NGonzale@jcvi.org
lab head
Yanbao Yu
contact affiliation	J. Craig Venter Institute
contact email	yayu@jcvi.org
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD017936
     1. Label: PRIDE project
     2. Name: Quantitative Proteomic and Phosphoproteomic Analyses of MLKL -/- mouse heart in response to influenza virus infection