PXD017892

PXD017892 is an original dataset announced via ProteomeXchange.

Title	altered bovine lymphocyte secretome after pokeweed mitogen stimulation
Description	Vaccination with a new vaccine against bovine viral diarrhea (BVD) caused unwanted immune reactions through alloreactive antibody production in 5–10% of vaccinated cows. Transfer of these alloreactive antibodies via colostrum caused highly lethal (90%) bovine neonatal pancytopenia (BNP) in calves. Despite the assumption of an immune deviant lymphocyte (PBL) phenotype, the exact immunological mechanisms driving these unwanted immune reactions are not fully understood to date. To gain deeper insight into these mechanisms, we analyzed the PBL secretome from alloreactive antibody producers (BNP cows) and non-alloreactive responders (controls) after stimulation with pokeweed mitogen (PWM).
HostingRepository	PRIDE
AnnounceDate	2022-02-23
AnnouncementXML	Submission_2022-02-23_03:21:43.437.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roxane Degroote
SpeciesList	scientific name: Bos taurus (Bovine); NCBI TaxID: 9913;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-05 01:47:04	ID requested
⏵ 1	2022-02-23 03:21:43	announced

Dataset with its publication pending

submitter keyword: polyclonal cell stimulation, cow, immune system, bovine neonatal pancytopenia, deviant immune reactions, vaccine, LTQ Orbitrap XL.

Cornelia Annette Deeg
contact affiliation	Chair of Physiology, Department of Veterinary Sciences, LMU Munich
contact email	deeg@tiph.vetmed.uni-muenchen.de
lab head
Roxane Degroote
contact affiliation	LMU Munich, Veterinary Sciences, Chair of Physiology, Lena-Christ-Straße 48, 82152 Planegg/Martinsried, Germany
contact email	r.degroote@lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD017892

PRIDE project URI

• PRIDE
  1. PXD017892
     1. Label: PRIDE project
     2. Name: altered bovine lymphocyte secretome after pokeweed mitogen stimulation