PXD017849

PXD017849 is an original dataset announced via ProteomeXchange.

Title	High Fructose-Driven Epigenetic and Metabolic Reprogramming in Glomerular Podocyte
Description	High fructose diet has been proposed as a major contributor to metabolic syndrome, which is usually accompanied with proteinuria due to glomerular podocyte injury. However, the underlying pathological mechanisms of fructose-induced podocyte injury remain elusive. In this study, we have used an iTRAQ based quantitative proteomic strategy to comprehensively characterize the dynamic proteome changes in glomeruli of high fructose-fed rats, and revealed global fructose-induced glomerular metabolic reprogramming at four different stages during the progression of high fructose modeling.
HostingRepository	PRIDE
AnnounceDate	2022-05-19
AnnouncementXML	Submission_2022-05-19_04:29:52.579.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lei Fang
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-03 09:22:30	ID requested
⏵ 1	2022-05-19 04:29:53	announced

Wu WY, Wang ZX, Li TS, Ding XQ, Liu ZH, Yang J, Fang L, Kong LD, SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway. Redox Biol, 52():102303(2022) [pubmed]

submitter keyword: Rat, high-fructose diet, podocyte injury, iTRAQ, metabolic reprogramming, mitochondria dysfunction, epigenetic mechanism.

Lei Fang
contact affiliation	Medical School of Nanjing University, Nanjing, 210093, China.
contact email	njfanglei@nju.edu.cn
lab head
Lei Fang
contact affiliation	Nanjing University Medical School
contact email	njfanglei@nju.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/05/PXD017849

PRIDE project URI

• PRIDE
  1. PXD017849
     1. Label: PRIDE project
     2. Name: High Fructose-Driven Epigenetic and Metabolic Reprogramming in Glomerular Podocyte