PXD017840

PXD017840 is an original dataset announced via ProteomeXchange.

Title	Complexome profiling of human cybrids laking mitochondrial genes Cox1 or Cox2
Description	Mitochondrial respiratory chain (MRC) complexes I, III and IV are associated into large molecular structures named supercomplexes (SCs) or respirasomes, whose functional roles remain to be fully understood. Biochemical analyses in a diversity of OXPHOS-deficient cellular and animal models support the idea that one of the SCs function is to confer stability to individual MRC complexes, in particular to complex I (CI). To gain insight into the mechanisms that regulate the structural interdependences among MRC complexes, we performed complexome profiling of human cybrids laking mitochondrial genes Cox1 or Cox2 and compared protein assemblies and intermediates to control 143B cells.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:08:19.631.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ilka Wittig
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-03 01:48:35	ID requested
1	2020-06-30 23:48:24	announced
⏵ 2	2024-10-22 05:08:27	announced	2024-10-22: Updated project metadata.

10.15252/embj.2019103912;

Lobo-Jarne T, P, é, rez-P, é, rez R, Fontanesi F, Tim, ó, n-G, ó, mez A, Wittig I, Pe, ñ, as A, Serrano-Lorenzo P, Garc, í, a-Consuegra I, Arenas J, Mart, í, n MA, Barrientos A, Ugalde C, Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes. EMBO J, 39(14):e103912(2020) [pubmed]

submitter keyword: cybrids,mitochondria, supercomplexes, complexome profiling

Cristina Ugalde
contact affiliation	Laboratory of Mitochondrial Disorders, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain
contact email	cugalde@h12o.es
lab head
Ilka Wittig
contact affiliation	Functional Proteomics, Goethe University, Frankfurt am Main , Germany
contact email	wittig@med.uni-frankfurt.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/07/PXD017840

PRIDE project URI

• PRIDE
  1. PXD017840
     1. Label: PRIDE project
     2. Name: Complexome profiling of human cybrids laking mitochondrial genes Cox1 or Cox2