PXD017809 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Non-metabolic PHGDH facilitates cMyc to urge advanced liver cancer |
Description | Metabolic dysregulation is an important feature of malignant tumors. Serine synthesis pathway (SSP) reshapes tumor cells to enhance their growth and survival capabilities, especially under serine starvation. However, whether and how SSP is involved in the progression of liver cancer has not been clearly stated. We applied a combination of quantitative proteomics and transcriptomics and discovered the increased expression of PHGDH and PSAT1 in mice liver cancer induced by SB. PHGDH is the first rating-limited enzyme of SSP and the conditional knockout of PHGDH in liver impaired the advanced liver cancer formation. However, the specific inhibition of enzymatic activity of PHGDH in liver has no obvious suppressive effect on advanced liver cancer. Further, we explored a non-metabolic function of PHGDH, which used its ACT domain to bind and regulate cMyc transcriptional activity, then selectively activated genes expression of Lcn2, Got1, Fabp5 and Psat1, indicating PHGDH drives/links multiple metabolic pathways and augmented its function through its non-metabolic role. In addition, the mutant p53 would release the suppression of PHGDH in mice liver cancer model and clinical liver cancer samples. Hence, the mutant p53/PHGDH/cMyc axis could be a potential target to cure advanced liver cancer. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:54:50.665.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | zhu sam |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-03-02 01:53:23 | ID requested | |
1 | 2023-07-20 10:49:00 | announced | |
2 | 2023-11-14 09:02:35 | announced | 2023-11-14: Updated project metadata. |
⏵ 3 | 2024-10-22 05:54:54 | announced | 2024-10-22: Updated project metadata. |
Publication List
Zhu H, Yu H, Zhou H, Zhu W, Wang X, Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer. Adv Sci (Weinh), 10(17):e2205818(2023) [pubmed] |
10.1002/advs.202205818; |
Keyword List
submitter keyword: serine synthesis, hepatocellular carcinoma,PHGDH, proteome |
Contact List
Xiongjun Wang |
contact affiliation | Shanghai Institue of Nutrition and Health, CAS |
contact email | xjwang02@sibcb.ac.cn |
lab head | |
zhu sam |
contact affiliation | sibs |
contact email | zhw@simm.ac.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD017809 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD017809
- Label: PRIDE project
- Name: Non-metabolic PHGDH facilitates cMyc to urge advanced liver cancer