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PXD017809

PXD017809 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNon-metabolic PHGDH facilitates cMyc to urge advanced liver cancer
DescriptionMetabolic dysregulation is an important feature of malignant tumors. Serine synthesis pathway (SSP) reshapes tumor cells to enhance their growth and survival capabilities, especially under serine starvation. However, whether and how SSP is involved in the progression of liver cancer has not been clearly stated. We applied a combination of quantitative proteomics and transcriptomics and discovered the increased expression of PHGDH and PSAT1 in mice liver cancer induced by SB. PHGDH is the first rating-limited enzyme of SSP and the conditional knockout of PHGDH in liver impaired the advanced liver cancer formation. However, the specific inhibition of enzymatic activity of PHGDH in liver has no obvious suppressive effect on advanced liver cancer. Further, we explored a non-metabolic function of PHGDH, which used its ACT domain to bind and regulate cMyc transcriptional activity, then selectively activated genes expression of Lcn2, Got1, Fabp5 and Psat1, indicating PHGDH drives/links multiple metabolic pathways and augmented its function through its non-metabolic role. In addition, the mutant p53 would release the suppression of PHGDH in mice liver cancer model and clinical liver cancer samples. Hence, the mutant p53/PHGDH/cMyc axis could be a potential target to cure advanced liver cancer.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:54:50.665.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterzhu sam
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-03-02 01:53:23ID requested
12023-07-20 10:49:00announced
22023-11-14 09:02:35announced2023-11-14: Updated project metadata.
32024-10-22 05:54:54announced2024-10-22: Updated project metadata.
Publication List
Zhu H, Yu H, Zhou H, Zhu W, Wang X, Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer. Adv Sci (Weinh), 10(17):e2205818(2023) [pubmed]
10.1002/advs.202205818;
Keyword List
submitter keyword: serine synthesis, hepatocellular carcinoma,PHGDH, proteome
Contact List
Xiongjun Wang
contact affiliationShanghai Institue of Nutrition and Health, CAS
contact emailxjwang02@sibcb.ac.cn
lab head
zhu sam
contact affiliationsibs
contact emailzhw@simm.ac.cn
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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