PXD017802

PXD017802 is an original dataset announced via ProteomeXchange.

Title	Testis proteome of Trypanosoma cruzi infected mice
Description	Male CD-1 mice (N=8) were intraperitoneally infected by culture-derived Trypanosoma cruzi trypomastigotes of the Brazil strain. One group (N=4) was treated with an antitrypanosomal drug (nifurtimox) on day 74 post-infection (chronic phase) for 20 days. A group of uninfected mice (N=3) was also included as control. All groups (N=11) were enthanized on day 110 post-infection, testes were collected and subjected to 2D-LC-MS/MS analysis. Label-free quantitation revealed that the testes of T. cruzi-infected mice had an altered proteome pattern relative to treated mice and uninfected controls. The analysis also demonstrated that the left and right testes had different proteomic profiles in infected animals.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:23:47.875.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Momar Ndao
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	maXis

Revision	Datetime	Status	ChangeLog Entry
0	2020-03-02 00:08:21	ID requested
1	2023-03-10 13:33:36	announced
⏵ 2	2023-11-14 08:23:50	announced	2023-11-14: Updated project metadata.

Golizeh M, Nam J, Chatelain E, Jackson Y, Ohlund LB, Rasoolizadeh A, Camargo FV, Mahrouche L, Furtos A, Sleno L, Ndao M, New metabolic signature for Chagas disease reveals sex steroid perturbation in humans and mice. Heliyon, 8(12):e12380(2022) [pubmed]

submitter keyword: testis, proteomics, Chagas disease, mouse,Trypanosoma cruzi, LC-MS/MS

Momar Ndao
contact affiliation	Department of Medicine, McGill University, Montreal, Quebec, Canada
contact email	momar.ndao@mcgill.ca
lab head
Momar Ndao
contact affiliation	McGill University
contact email	momar.ndao@mcgill.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/03/PXD017802

PRIDE project URI

• PRIDE
  1. PXD017802
     1. Label: PRIDE project
     2. Name: Testis proteome of Trypanosoma cruzi infected mice