PXD017772

PXD017772 is an original dataset announced via ProteomeXchange.

Title	DICER-interacting partners in juvenile mouse testes
Description	DICER has a well-characterized role in the processing of microRNAs (miRNAs) and small interfering RNAs (siRNA) that are important for post-transcriptional gene regulation. Emerging evidence suggests that DICER also has several non-canonical functions beyond miRNA/siRNA biogenesis, for example in transcriptional gene silencing at the chromatin level, as well as in RNA degradation and maintenance of genomic integrity. We have shown that the function of DICER in germ cells is essential for normal spermatogenesis; male mice lacking DICER in postnatal male germ cells are infertile due to severe defects in haploid differentiation. To better understand the function of DICER in male germ cells, we immunoprecipitated DICER from juvenile mouse testes and performed mass spectrometric analysis to identify DICER-interacting proteins.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:06:38.065.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ram Prakash Yadav
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-28 03:21:34	ID requested
1	2020-06-03 00:53:35	announced
⏵ 2	2024-10-22 05:06:40	announced	2024-10-22: Updated project metadata.

Yadav RP, M, ä, kel, ä JA, Hyss, ä, l, ä H, Cisneros-Montalvo S, Kotaja N, DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis. Nucleic Acids Res, 48(13):7135-7153(2020) [pubmed]

10.1093/nar/gkaa460;

submitter keyword: mouse testis, germ cells,DICER

Noora Kotaja
contact affiliation	Noora Kotaja, Associate Professor, Institute of Biomedicine, University of Turku, Finland
contact email	noora.kotaja@utu.fi
lab head
Ram Prakash Yadav
contact affiliation	University of Turku
contact email	ramprakash.yadav@utu.fi
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD017772

PRIDE project URI

• PRIDE
  1. PXD017772
     1. Label: PRIDE project
     2. Name: DICER-interacting partners in juvenile mouse testes