PXD017751
PXD017751 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Global proteome profiling of human livers upon ischemia/reperfusion treatment |
| Description | Hepatic ischemia/reperfusion (I/R) injury represents a major risk factor for liver transplantation and is related to graft dysfunction and acute/chronic rejection. However, a significant part of these processes remain poorly characterized. To reveal differences in the proteome during liver I/R injury, we collected human liver biopsy samples during hepatectomy before and after the Pringle maneuver and conducted a TMT-based proteomic analysis through quantitative high-throughput mass spectrometry. We used a fold-change threshold of 1.3 and a t-test p-value<0.05 as the criteria to identify 5,257 total quantifiable proteins. The levels of 142 proteins were increased, while the levels of 103 proteins were decreased in response to hepatic I/R treatment. Bioinformatic analysis further revealed that these differentially expressed proteins are mainly involved in multiple biological functions and enzyme-regulated metabolic pathways. Most proteins whose expression was changed are related to the defense, immune and inflammatory responses as well as lipid and steroid metabolic processes. The upregulated proteins were found to be involved in immunity and inflammatory responses, and downregulated proteins were enriched in metabolic pathways. This study therefore may provide a research direction for the design of new therapeutic strategies for hepatic ischemia/reperfusion injury. |
| HostingRepository | iProX |
| AnnounceDate | 2020-02-26 |
| AnnouncementXML | Submission_2020-02-26_17:57:07.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Jian Du |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2020-02-26 17:46:10 | ID requested | |
| ⏵ 1 | 2020-02-26 17:57:08 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Hepatic ischemia/reperfusion, Human, Proteomics, TMT |
Contact List
| Lijian Chen | |
|---|---|
| contact affiliation | Anhui Medical University |
| contact email | chenlijian77@126.com |
| lab head | |
| Jian Du | |
| contact affiliation | Anhui medical university |
| contact email | dujane@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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