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PXD017716

PXD017716 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtective effect of Vigna unguiculata extract against aging and neurodegeneration
DescriptionAging and age-related neurodegeneration are among the major challenges because of the progressive increase in the number of elder people in the wold population. Nutrition, which has important long-term consequences for health, is actually considered a means to prevent diseases and to reach a healthy aging. Here we investigate the role of Vigna unguiculata beans on senescence by using Saccharomyces cerevisiae and Drosophila melanogaster as model systems. Aqueous extract, mainly containing starch, proteins and amino acids, extends chronological lifespan in yeast cells, showing a remarkable synergistic effect in combination with caloric restriction. The extension of yeast longevity requires both the anti-aging Snf1/AMPK and the pro-aging Ras2/PKA pathways. A significant marked increase of lifespan was observed also in fruit flies supplemented with the V. unguiculata extract, which is accompanied by the increased expression of FOXO, NOTCH, SIRT1 and heme oxygenase (HO) genes, already known to be required for the extension of fruit fly longevity. α-synuclein forms toxic intracellular protein inclusions in Parkinson’s disease (PD) and actually preventing α-synuclein self-assembly has become one of the most promising approaches for the treatment of this neurodegenerative disorder. Here, we report that in vitro aggregation of -synuclein, as well as its toxicity in yeast and in neuroblastoma cells, are strongly decreased in the presence of bean extract. In addition, in a Caenorhabditis elegans model of PD that expresses α-synuclein, Vigna unguiculate extract substantially reduces the number of the age-dependent degeneration of the cephalic dopaminergic neurons. Overall, our data support the role of Vigna unguiculata beans as a functional food, worth to be further explored in order to develop lead molecules for therapeutic intervention in age-related disorders.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:26:36.350.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSimona Nonnis
SpeciesList scientific name: 'Phaseolus vulgaris' phytoplasma; NCBI TaxID: 188912;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-02-25 06:32:01ID requested
12021-09-08 13:45:41announced
22024-10-22 05:26:38announced2024-10-22: Updated project metadata.
Publication List
Tripodi F, Lombardi L, Guzzetti L, Panzeri D, Milanesi R, Leri M, Bucciantini M, Angeloni C, Beghelli D, Hrelia S, Onorato G, Di Schiavi E, Falletta E, Nonnis S, Tedeschi G, Labra M, Coccetti P, extract against aging and neurodegeneration. Aging (Albany NY), 12(19):19785-19808(2020) [pubmed]
10.18632/aging.104069;
Keyword List
submitter keyword: nutrition, Parkinson’s disease (PD),proteomics, functional food, Saccharomyces cerevisiae, nano LC-MS/MS, Caenorhabditis elegans, human -synuclein, Drosophila melanogaster
Contact List
Simona Nonnis
contact affiliationDepartment of Veterinary Medicine, University of Milan
contact emailsimona.nonnis@unimi.it
lab head
Simona Nonnis
contact affiliationUniversity of Milan
contact emailsimona.nonnis@unimi.it
dataset submitter
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Dataset FTP location
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