PXD017671

PXD017671 is an original dataset announced via ProteomeXchange.

Title	Proteomic changes of the liver in the absence of growth hormone (GH) actions
Description	The liver is a central target organ of growth hormone (GH), which stimulates the synthesis of insulin-like growth factor 1 (IGF1) and affects multiple biochemical pathways. A systematic multi-omics analysis of GH actions in the liver has not been performed. GH receptor (GHR) deficiency is a unique model for studying consequences of lacking GH actions. In this study, we used molecular profiling techniques to capture a broad spectrum of these effects in the liver of a clinically relevant large animal model.
HostingRepository	PRIDE
AnnounceDate	2020-03-30
AnnouncementXML	Submission_2020-06-12_04:12:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Fröhlich
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-20 23:14:03	ID requested
1	2020-03-30 00:07:25	announced
⏵ 2	2020-06-12 04:12:55	announced	2020-06-12: Updated publication reference for PubMed record(s): 32277923.

Riedel EO, Hinrichs A, Kemter E, Dahlhoff M, Backman M, Rathkolb B, Prehn C, Adamski J, Renner S, Blutke A, de Angelis MH, Bidlingmaier M, Schopohl J, Arnold GJ, Fr, ö, hlich T, Wolf E, Functional changes of the liver in the absence of growth hormone (GH) action - Proteomic and metabolomic insights from a GH receptor deficient pig model. Mol Metab, 36():100978(2020) [pubmed]

submitter keyword: Liver

Growth hormone

Laron syndrome

Pig model

Proteomics

Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis Genzentrum Ludwig-Maximilians-Universität München Feodor-Lynen-Str. 25 D-81377 München Germany
contact email	frohlich@genzentrum.lmu.de
lab head
Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis Gene Center Munich Ludwig-Maximilians-Universität Munich (LMU) Feodor-Lynen-Str. 25 81377 Munich Germany
contact email	frohlich@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/03/PXD017671

PRIDE project URI

• PRIDE
  1. PXD017671
     1. Label: PRIDE project
     2. Name: Proteomic changes of the liver in the absence of growth hormone (GH) actions