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PXD017644

PXD017644 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of phosphorylation sites in the IGF-1 Receptor
DescriptionAlthough Insulin-like Growth Factor (IGF-1) signaling promotes tumor growth and cancer progression, IGF-1 Receptor-targeted therapies have shown poor clinical efficacy. The mechanistic basis for this is unclear as is our understanding of what distinguishes IGF-1R signaling from the closely related Insulin receptor (IR) signaling. This study illuminates both issues. A site in the IGF-1R C-terminal tail incorporating two tyrosines that are not present in the Insulin receptor (IR) was previously shown to be essential for IGF-1-mediated cancer cell survival, migration and tumorigenic growth. Here, we establish that the Y1250/Y1251 site is autophosphorylated in a cell adhesion-dependent manner.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:03:46.566.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRosemary O'Connor
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-02-19 23:38:12ID requested
12020-05-14 23:44:16announced
22020-06-11 22:53:49announced2020-06-12: Updated publication reference for PubMed record(s): 32457113.
32024-10-22 05:03:51announced2024-10-22: Updated project metadata.
Publication List
10.1126/scisignal.aba3176;
Rieger L, O'Shea S, Godsmark G, Stanicka J, Kelly G, O'Connor R, . Sci Signal, 13(633):(2020) [pubmed]
Keyword List
submitter keyword: Tyr1131, Tyr1135, Tyr1136,IGF-1, Tyr125051, IGF-1 Receptor
Contact List
Rosemary O'Connor
contact affiliationSchool of Biochemistry and Cell Biology, University College Cork, Cork, Ireland
contact emailr.oconnor@ucc.ie
lab head
Rosemary O'Connor
contact affiliationUniversity College Cork
contact emailr.oconnor@ucc.ie
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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