PXD017644
PXD017644 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Identification of phosphorylation sites in the IGF-1 Receptor |
Description | Although Insulin-like Growth Factor (IGF-1) signaling promotes tumor growth and cancer progression, IGF-1 Receptor-targeted therapies have shown poor clinical efficacy. The mechanistic basis for this is unclear as is our understanding of what distinguishes IGF-1R signaling from the closely related Insulin receptor (IR) signaling. This study illuminates both issues. A site in the IGF-1R C-terminal tail incorporating two tyrosines that are not present in the Insulin receptor (IR) was previously shown to be essential for IGF-1-mediated cancer cell survival, migration and tumorigenic growth. Here, we establish that the Y1250/Y1251 site is autophosphorylated in a cell adhesion-dependent manner. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:03:46.566.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rosemary O'Connor |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-02-19 23:38:12 | ID requested | |
1 | 2020-05-14 23:44:16 | announced | |
2 | 2020-06-11 22:53:49 | announced | 2020-06-12: Updated publication reference for PubMed record(s): 32457113. |
⏵ 3 | 2024-10-22 05:03:51 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1126/scisignal.aba3176; |
Rieger L, O'Shea S, Godsmark G, Stanicka J, Kelly G, O'Connor R, . Sci Signal, 13(633):(2020) [pubmed] |
Keyword List
submitter keyword: Tyr1131, Tyr1135, Tyr1136,IGF-1, Tyr125051, IGF-1 Receptor |
Contact List
Rosemary O'Connor | |
---|---|
contact affiliation | School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland |
contact email | r.oconnor@ucc.ie |
lab head | |
Rosemary O'Connor | |
contact affiliation | University College Cork |
contact email | r.oconnor@ucc.ie |
dataset submitter |
Full Dataset Link List
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD017644 |
PRIDE project URI |
Repository Record List
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