PXD017644

PXD017644 is an original dataset announced via ProteomeXchange.

Title	Identification of phosphorylation sites in the IGF-1 Receptor
Description	Although Insulin-like Growth Factor (IGF-1) signaling promotes tumor growth and cancer progression, IGF-1 Receptor-targeted therapies have shown poor clinical efficacy. The mechanistic basis for this is unclear as is our understanding of what distinguishes IGF-1R signaling from the closely related Insulin receptor (IR) signaling. This study illuminates both issues. A site in the IGF-1R C-terminal tail incorporating two tyrosines that are not present in the Insulin receptor (IR) was previously shown to be essential for IGF-1-mediated cancer cell survival, migration and tumorigenic growth. Here, we establish that the Y1250/Y1251 site is autophosphorylated in a cell adhesion-dependent manner.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:03:46.566.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rosemary O'Connor
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-19 23:38:12	ID requested
1	2020-05-14 23:44:16	announced
2	2020-06-11 22:53:49	announced	2020-06-12: Updated publication reference for PubMed record(s): 32457113.
⏵ 3	2024-10-22 05:03:51	announced	2024-10-22: Updated project metadata.

10.1126/scisignal.aba3176;

Rieger L, O'Shea S, Godsmark G, Stanicka J, Kelly G, O'Connor R, . Sci Signal, 13(633):(2020) [pubmed]

submitter keyword: Tyr1131, Tyr1135, Tyr1136,IGF-1, Tyr125051, IGF-1 Receptor

Rosemary O'Connor
contact affiliation	School of Biochemistry and Cell Biology, University College Cork, Cork, Ireland
contact email	r.oconnor@ucc.ie
lab head
Rosemary O'Connor
contact affiliation	University College Cork
contact email	r.oconnor@ucc.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD017644

PRIDE project URI

• PRIDE
  1. PXD017644
     1. Label: PRIDE project
     2. Name: Identification of phosphorylation sites in the IGF-1 Receptor