PXD017641 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Chemoproteomics of an NSD2-PWWP1 Chemical Probe |
Description | Here we use competitive chemoproteomics pulldowns followed by label-free quantitative LC-MS/MS to assess target engagement and selectivity profiles of UNC6934 and UNC7145, a chemical probe targeting the PWWP1 domain of NSD2 and its negative control counterpart, respectively. To this end, we used a biotinylated probe derivative (UNC7096) for streptavidin pulldowns from KMS-11 multiple myeloma cell lysates, including in the context of UNC7145 or UNC6934 competition. |
HostingRepository | PRIDE |
AnnounceDate | 2021-08-06 |
AnnouncementXML | Submission_2021-08-06_03:03:33.258.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Suzanne Ackloo |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos; Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-02-19 23:05:56 | ID requested | |
⏵ 1 | 2021-08-06 03:03:33 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: chemoproteomics, epigenetics, chemical probe, histone methyltransferase |
Contact List
Cheryl H Arrowsmith |
contact affiliation | Senior Scientist, Princess Margaret Cancer Center Medical Biophysics, University of Toronto |
contact email | cheryl.arrowsmith@uhnresearch.ca |
lab head | |
Suzanne Ackloo |
contact affiliation | University of Toronto |
contact email | suzanne.ackloo@utoronto.ca |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/08/PXD017641 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD017641
- Label: PRIDE project
- Name: Chemoproteomics of an NSD2-PWWP1 Chemical Probe