PXD017596

PXD017596 is an original dataset announced via ProteomeXchange.

Title	Cranial Irradiation Impairs Juvenile Social Behavior and Modulates Hippocampal Physiology
Description	Cranial and craniospinal irradiation are the oldest central nervous system prophylaxis treatments considered for pediatric patients with lymphoblastic leukemia (ALL). However, survivors of childhood ALL that received cranial radiotherapy are at increased risk for deficits in neurocognitive skills. The continuous and dynamic response of normal tissue after irradiation has been identified as one of the causative factors for cognitive changes after cranial radiation therapy. The aim of our study was to investigate the radiation effects on social behavior and neuronal morphology in the hippocampus of adult mice. Twenty-one-day-old male C57BL/6 mice were irradiated with the small-animal radiation research platform (SARRP). Animals were given a single 10-Gy dose of radiation of X-ray cranial radiation. One month following irradiation, animals underwent behavioral testing in the Three-Chamber Sociability paradigm. Radiation affected social discrimination during the third stage eliciting an inability to discriminate between the familiar and stranger mouse, while sham successfully spent more time exploring the novel stranger. Proteomic analysis revealed dysregulation of metabolic and signaling pathways associated with neurocognitive dysfunction such as mitochondrial dysfunction, Rac 1 signaling, and synaptogenesis signaling. We observed significant decreases in mushroom spine density in the Cornu Ammonis 2 of the hippocampus, which is associated sociability processing.
HostingRepository	PRIDE
AnnounceDate	2022-02-22
AnnouncementXML	Submission_2022-02-21_16:30:46.419.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD017596
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Stephanie Byrum
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	Orbitrap Fusion

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-18 09:06:29	ID requested
⏵ 1	2022-02-21 16:30:47	announced

Newton J, Brown T, Corley C, Alexander T, Trujillo M, McElroy T, Ntagwabira F, Wang J, Byrum SD, Allen AR, Cranial irradiation impairs juvenile social memory and modulates hippocampal physiology. Brain Res, 1748():147095(2020) [pubmed]

submitter keyword: Irradiation, hippocampus, dendritic spines

Antino R. Allen
contact affiliation	1. Division of Radiation Health, 2. Department of Pharmaceutical Sciences, 3. Neurobiology & Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR
contact email	ARAllen@uams.edu
lab head
Stephanie Byrum
contact affiliation	UAMS
contact email	sbyrum@uams.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD017596
     1. Label: PRIDE project
     2. Name: Cranial Irradiation Impairs Juvenile Social Behavior and Modulates Hippocampal Physiology