PXD017588

PXD017588 is an original dataset announced via ProteomeXchange.

Title	Global proteomic analysis deciphers the mechanism of action of plant derived oleic acid against Candida albicans virulence and biofilm formation
Description	Candida albicans is a commensal fungus in humans, mostly found on the mucosal surfaces of the mouth, gut, vagina and skin. Incidence of ever increasing invasive candidiasis in immunocompromised patients, alarming occurrence of antifungal resistance and insufficient diagnostic methods demand more focused research into C. albicans pathogenicity. Consequently, in the present study, oleic acid from Murraya koenigii was shown to have the efficacy to inhibit biofilm formation and virulence of Candida spp. Results of in vitro virulence assays and gene expression analysis, impelled to study the protein targets which are involved in the molecular pathways of C. albicans pathogenicity. Proteomic studies of differentially expressed proteins reveals that oleic acid induces oxidative stress responses and mainly targets the proteins involved in glucose metabolism, ergosterol biosynthesis, lipase production, iron homeostasis and amino acid biosynthesis. The current study emphasizes anti-virulent potential of oleic acid which can be used as a therapeutic agent to treat Candida infections.
HostingRepository	PRIDE
AnnounceDate	2020-05-27
AnnouncementXML	Submission_2020-05-26_16:49:06.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shunmugiah Karutha Pandian
SpeciesList	scientific name: Candida albicans (Yeast); NCBI TaxID: 5476;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	AXIMA Performance MALDI-TOF/TOF

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-18 06:24:04	ID requested
⏵ 1	2020-05-26 16:49:07	announced

Muthamil S, Prasath KG, Priya A, Precilla P, Pandian SK, Global proteomic analysis deciphers the mechanism of action of plant derived oleic acid against Candida albicans virulence and biofilm formation. Sci Rep, 10(1):5113(2020) [pubmed]

submitter keyword: Candida albicans, Oleic acid, 2D electrophoresis, MALDI-TOF-TOF

Dr. Shunmugiah Karutha Pandian
contact affiliation	Senior Professor anD Head Department of Biotechnology Alagappa University Karaikudi-630003 Tamil Nadu India
contact email	sk_pandian@rediffmail.com
lab head
Shunmugiah Karutha Pandian
contact affiliation	Department of Biotechnology, Alagappa University, Tamil Nadu-630003, India
contact email	sk_pandian@rediffmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD017588
     1. Label: PRIDE project
     2. Name: Global proteomic analysis deciphers the mechanism of action of plant derived oleic acid against Candida albicans virulence and biofilm formation