PXD017536

PXD017536 is an original dataset announced via ProteomeXchange.

Title	The secretome of skin cancer cells HaCat and A431
Description	Cutaneous squamous cell carcinoma (cSCC) is the most prominent tumor of non-melanoma skin cancers and the most aggressive tumor among keratinocyte carcinoma of the skin, showing a high potential for local invasion and metastasis. The cSCC incidences increased dramatically in recent years and the disease occurs more commonly than any other malignancy. The secretome of cancer cells is currently the focus of many studies in order to identify new marker proteins for different types of cancer and to investigate its influence on the tumor microenvironment. In our study we evaluated whether the secretome of cSCC cells has an impact on keratinocytes, the surrounding tissue cells of cSCC. Therefore, we analyzed and compared the secretome of human A431 cancer cells and of HaCaT keratinocytes by mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:02:07.448.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thomas Fröhlich
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-17 01:58:48	ID requested
1	2020-04-16 06:26:33	announced
⏵ 2	2024-10-22 05:02:13	announced	2024-10-22: Updated project metadata.

Hoesl C, Zanuttigh E, Fr, ö, hlich T, Philippou-Massier J, Krebs S, Blum H, Dahlhoff M, The secretome of skin cancer cells activates the mTOR/MYC pathway in healthy keratinocytes and induces tumorigenic properties. Biochim Biophys Acta Mol Cell Res, 1867(8):118717(2020) [pubmed]

10.1016/j.bbamcr.2020.118717;

submitter keyword: keratinocytes

mTOR

secretome

squamous cell carcinoma

Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis Genzentrum Ludwig-Maximilians-Universität München Feodor-Lynen-Str. 25 D-81377 München Germany
contact email	frohlich@genzentrum.lmu.de
lab head
Thomas Fröhlich
contact affiliation	Laboratory for Functional Genome Analysis Gene Center Munich Ludwig-Maximilians-Universität Munich (LMU) Feodor-Lynen-Str. 25 81377 Munich Germany
contact email	frohlich@genzentrum.lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/04/PXD017536

PRIDE project URI

• PRIDE
  1. PXD017536
     1. Label: PRIDE project
     2. Name: The secretome of skin cancer cells HaCat and A431