PXD017531

PXD017531 is an original dataset announced via ProteomeXchange.

Title	Interaction mapping of human condensin I and condensin II complexes using DSBU-cross-linking and mass spectrometry
Description	Human condensin I and condensin II complexes play essential roles in chromatin condensation during the cell division process. Both complexes use ATP as the energy source to pack extended chromatin into the short form of chromosome. In order to understand the mechanism of their function, we performed cross-linking mass spectrometry (XL-MS) analyses of both complexes and mapped the inter-molecular and intra-molecular interactions of the subunits.
HostingRepository	PRIDE
AnnounceDate	2020-05-25
AnnouncementXML	Submission_2020-05-24_22:36:32.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Dongqing Pan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-16 23:49:57	ID requested
⏵ 1	2020-05-24 22:36:33	announced

Kong M, Cutts EE, Pan D, Beuron F, Kaliyappan T, Xue C, Morris EP, Musacchio A, Vannini A, Greene EC, Human Condensin I and II Drive Extensive ATP-Dependent Compaction of Nucleosome-Bound DNA. Mol Cell, 79(1):99-114.e9(2020) [pubmed]

curator keyword: Biological

submitter keyword: DSBU, cross-linking, XL-MS, Q-Exactive, human, chromatin, chromosome, condensin, protein complex

Andrea Musacchio
contact affiliation	Department of Mechanistic Cell Biology, Max-Planck Institute of Molecular Physiology, 9 Otto-Hahn-Str. 11, 44227 Dortmund, Germany
contact email	andrea.musacchio@mpi-dortmund.mpg.de
lab head
Dongqing Pan
contact affiliation	Department of Mechanistic Cell Biology, Max-Planck Institute of Molecular Physiology, 9 Otto-Hahn-Str. 11, 44227 Dortmund
contact email	dongqing.pan@mpi-dortmund.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/05/PXD017531

PRIDE project URI

• PRIDE
  1. PXD017531
     1. Label: PRIDE project
     2. Name: Interaction mapping of human condensin I and condensin II complexes using DSBU-cross-linking and mass spectrometry