PXD017508

PXD017508 is an original dataset announced via ProteomeXchange.

Title	The pan-Sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line
Description	The involvement of sirtuins (SIRTs) in modulating metabolic and stress response pathways is attracting growing scientific interest. Some SIRT family members are located in mitochondria, dynamic organelles that perform several crucial functions essential for eukaryotic life. Mitochondrial dysfunction has emerged as having a key role in a number of human diseases, including cancer. Here, we investigated mitochondrial damage resulting from treatment with a recently characterized pan-SIRT inhibitor, MC2494. MC2494 was able to block mitochondrial biogenesis and function in terms of ATP synthesis and energy metabolism, suggesting that it might orchestrate cell response to metabolic stress and thereby interfere with tumorigenesis. Targeting mitochondrial function could thus be considered a potential anticancer strategy for use in clinical therapy.
HostingRepository	PRIDE
AnnounceDate	2021-09-08
AnnouncementXML	Submission_2021-09-08_14:43:56.289.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Angela Chambery
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-14 01:26:49	ID requested
⏵ 1	2021-09-08 14:43:57	announced

Carafa V, Russo R, Della Torre L, Cuomo F, Dell'Aversana C, Sarno F, Sgueglia G, Di Donato M, Rotili D, Mai A, Nebbioso A, Cobellis G, Chambery A, Altucci L, The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line. Front Oncol, 10():820(2020) [pubmed]

submitter keyword: Sirtuins, mitochondria, leukemia, orbitrap Q-Exactive, human

Angela Chambery
contact affiliation	Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche Università degli Studi della Campania“Luigi Vanvitelli”
contact email	angela.chambery@unicampania.it
lab head
Angela Chambery
contact affiliation	University of Campania "Luigi Vanvitelly"
contact email	angela.chambery@unicampania.it
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/09/PXD017508

PRIDE project URI

• PRIDE
  1. PXD017508
     1. Label: PRIDE project
     2. Name: The pan-Sirtuin inhibitor MC2494 regulates mitochondrial function in a leukemia cell line