PXD017503

PXD017503 is an original dataset announced via ProteomeXchange.

Title	Dynamic protein modification of the malaria parasite Plasmodium falciparum and the infected erythrocytes
Description	Plasmodium falciparum, a lethal protozoan, undergoes a complex extra- and intraerythrocytic development cycle that requires intricate and flexible regulatory mechanisms in order to facilitate reproduction and maintain the parasite’s resistance to environmental stress. Protein post-translational modifications (PTMs) are essential processes following protein biogenesis that allow proteins to fulfill their diverse biological functions. Here, we present comprehensive PTMomic profiling of both P. falciparum and its erythrocytic host cells during the 48 hours after infection. Fine mappings of each protein in both P. falciparum and the infected red blood cells (pRBCs) were accomplished. More than two-thirds of the parasite and its host cell proteins underwent extensive and dynamic modification throughout the erythrocytic developmental stage of the malarial parasite. Apart from the finding that PTMs actively regulated P. falciparum gene activation and silencing, the key molecules involved in the host-parasite interaction and pathogenesis were essentially modified. The establishment of an atlas of PTMomes of P. falciparum and its host erythrocytes will promote a deeper understanding of the parasite biology and will provide a basis for the search for novel antimalarials.
HostingRepository	PRIDE
AnnounceDate	2020-11-09
AnnouncementXML	Submission_2020-11-09_04:52:51.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jianhua Wang
SpeciesList	scientific name: Plasmodium falciparum; NCBI TaxID: 5833; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; acetylated residue
Instrument	Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-13 02:41:02	ID requested
⏵ 1	2020-11-09 04:52:51	announced

submitter keyword: Plasmodium falciparum

Infected erythrocytes

Intraerythrocytic development cycle

Dynamic epigenetics

Phosphorylation

Acetylation

Crotonylation

2-hydroxyisobutyrylation

N-glycosylation

Ubiquitination.

Qijun Chen
contact affiliation	Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Shenyang Agricultural University, 120 Dongling Road, Shengyang 110866, P.R. China
contact email	qijunchen759@syau.edu.cn
lab head
Jianhua Wang
contact affiliation	1. Key Laboratory of Livestock Infectious Diseases in Northeast China, Ministry of Education, Shenyang Agricultural University, 120 Dongling Road, Shengyang 110866, P.R. China 2. The Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China.
contact email	wangjianhua0326@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/11/PXD017503

PRIDE project URI

• PRIDE
  1. PXD017503
     1. Label: PRIDE project
     2. Name: Dynamic protein modification of the malaria parasite Plasmodium falciparum and the infected erythrocytes