PXD017494 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Data Descriptor: Proteomic profiling across breast cancer cell lines and models |
Description | We performed quantitative proteomics and phosphoproteomics of 43 human-derived breast cancer cell lines to a depth of 11, 000 proteins and 45,000 phosphopeptides respectively. The resulting high-throughput datasets were assessed for quality and reproducibility. We used the two omics datasets to identify and characterize the subtypes of breast cancer and showed that they conform with known transcriptional subtypes, revealing that molecular subtypes are preserved even in under-sampled molecular feature datasets. The datasets are made freely available as a public resource on the LINCS portal. We anticipate that these datasets, either in isolation or combination with measurements of complementary molecular features, can be mined for the purpose of predicting drug response, informing context in mathematical models of signalling pathways, inferring cell-type or subtype specific pathways activities of unperturbed cellular states, and identifying markers of sensitivity or resistance to therapeutics. |
HostingRepository | PRIDE |
AnnounceDate | 2023-07-03 |
AnnouncementXML | Submission_2023-07-03_11:33:09.463.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | MarianKalocsay |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-02-13 02:39:58 | ID requested | |
⏵ 1 | 2023-07-03 11:33:09 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Human, Breast Cancer, Cancer Cell Lines, LINCS |
Contact List
Peter K. Sorger,PhD |
contact affiliation | Otto Krayer Professor Department of Systems Biology Head of the Harvard Program in Therapeutic Sciences - HiTS Harvard Medical School (lab head) |
contact email | peter_sorger@hms.harvard.edu |
lab head | |
MarianKalocsay |
contact affiliation | Harvard Medical School |
contact email | marian_kalocsay@hms.harvard.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/07/PXD017494 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD017494
- Label: PRIDE project
- Name: Data Descriptor: Proteomic profiling across breast cancer cell lines and models