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PXD017393

PXD017393 is an original dataset announced via ProteomeXchange.

Dataset Summary
Titleproteome landscapes of pancreatic cancer human-in-mouse patient-derived xenograft (PDX) models.
DescriptionPancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of relatively few tumor cells surrounded a heterocellular non-cancerous cell population embedded in extracellular matrix, collectively named stroma. Despite the recognition that the stroma is an important contributor to the typically poor outcome of PDAC, its analysis has been hampered by the analysis of bulk tissue. Here we present a landscape of human epithelial PDAC cells of primary tumors (n=6) and metastases (n=4) in a mouse stroma background.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:27:14.254.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSander Piersma
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-02-05 03:00:49ID requested
12021-09-08 18:20:14announced
22024-10-22 05:27:22announced2024-10-22: Updated project metadata.
Publication List
10.1172/jci.insight.138290;
Le Large TY, Mantini G, Meijer LL, Pham TV, Funel N, van Grieken NC, Kok B, Knol J, van Laarhoven HW, Piersma SR, Jimenez CR, Kazemier G, Giovannetti E, Bijlsma MF, Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets. JCI Insight, 5(15):(2020) [pubmed]
Keyword List
submitter keyword: patient-derived xenograft , human, mouse, PDX, pancreatic cancer, stroma
Contact List
Connie Ramona Jimenez
contact affiliationAmsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands
contact emailc.jimenez@amsterdamumc.nl
lab head
Sander Piersma
contact affiliationOncoProteomics Laboratory, dept of Medical Oncology, VUmc Medical Center, Amsterdam, The Netherlands
contact emails.piersma@vumc.nl
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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