PXD017383

PXD017383 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Identification of Xenopus laevis egg extract fraction stimulating somatic DNA replication through LC-MSMS
Description	In several metazoans the number of active replication origins in embryonic nuclei is higher than in somatic ones, ensuring rapid genome duplication during synchronous embryonic cell divisions. High replication origin density can be restored by somatic nuclear reprogramming. However, mechanisms underlying high replication origin density formation coupled to rapid cell cycles are poorly understood. Here, we characterized a fraction of Xenopus egg extract able to stimulate somatic DNA replication.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:00:52.460.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Paolo Soffientini
SpeciesList	scientific name: Xenopus laevis (African clawed frog); NCBI TaxID: 8355;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2020-02-04 08:33:36	ID requested
1	2020-03-19 03:36:57	announced
⏵ 2	2024-10-22 05:01:00	announced	2024-10-22: Updated project metadata.

Publication List

10.1038/s41467-020-15180-5;
Falbo L, Raspelli E, Romeo F, Fiorani S, Pezzimenti F, Casagrande F, Costa I, Parazzoli D, Costanzo V, SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development. Nat Commun, 11(1):1345(2020) [pubmed]

10.1038/s41467-020-15180-5;

Falbo L, Raspelli E, Romeo F, Fiorani S, Pezzimenti F, Casagrande F, Costa I, Parazzoli D, Costanzo V, SSRP1-mediated histone H1 eviction promotes replication origin assembly and accelerated development. Nat Commun, 11(1):1345(2020) [pubmed]

Keyword List

ProteomeXchange project tag: Human Proteome Project
submitter keyword: LC-MSMS,DNA replication, somatic, Xenopus

ProteomeXchange project tag: Human Proteome Project

submitter keyword: LC-MSMS,DNA replication, somatic, Xenopus

Contact List

Vincenzo Costanzo
contact affiliation	IFOM - Fondazione Istituto FIRC di Oncologia Molecolare Via Adamello, 16 20139 Milano MI Italy
contact email	vincenzo.costanzo@ifom.eu
lab head
Paolo Soffientini
contact affiliation	Cogentech-IFOM
contact email	paolo.soffientini@cogentech.it
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/03/PXD017383
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/03/PXD017383

PRIDE project URI

Repository Record List

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