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PXD017349

PXD017349 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIron deficiency response of Corynebacterium glutamicum
DescriptionThe response to iron limitation of the Gram-positive soil bacterium Corynebacterium glutamicum was analyzed with respect to proteome during growth in glucose minimal medium. C. glutamicum cells were grown at regular (36 µM) and low (1 µM) iron concentrations and harvested in the late exponential growth phase. Between 1056 and 1357 proteins were detected (1% false discovery rate, FDR) in the measurements of three biological replicates including technical replicates each for low and high iron conditions with a proteomic shotgun analysis using nanoLC-MS/MS, covering in total 1555 proteins. By SWATH-MS measurements, relative levels of 1123 proteins could be quantified. Thereof, 66 proteins exhibited at least two-fold altered ratios with a p-value ≤0.05 in iron-deprived cells compared to the cells cultivated with 36 μM iron. 38 proteins showed a ≥2-fold higher level under iron limitation, 16 of which were members of the DtxR regulon. The levels of 28 proteins were at least 2-fold lower under iron limitation, 10 of which were members of the RipA regulon.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:02:10.492.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterTino Polen
SpeciesList scientific name: Bacteria; NCBI TaxID: NCBITaxon:2; scientific name: Corynebacterium glutamicum ATCC 13032; NCBI TaxID: 196627;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-01-31 02:05:24ID requested
12020-04-14 23:12:49announced
22024-10-22 05:02:18announced2024-10-22: Updated project metadata.
Publication List
K, ü, berl A, Mengus-Kaya A, Polen T, Bott M, The Iron Deficiency Response of Corynebacterium glutamicum and a Link to Thiamine Biosynthesis. Appl Environ Microbiol, 86(10):(2020) [pubmed]
10.1128/aem.00065-20;
Keyword List
curator keyword: Biological
submitter keyword: Corynebacterium glutamicum,iron
Contact List
Tino Polen
contact affiliationIBG-1: Biotechnology Forschungszentrum Juelich
contact emailt.polen@fz-juelich.de
lab head
Tino Polen
contact affiliationForschungszentrum Jülich
contact emailt.polen@fz-juelich.de
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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