PXD017345 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | SugarPy facilitates the universal, discovery-driven analysis of intact glycopeptides |
Description | Protein glycosylation is a complex post-translational modification with crucial cellular functions in all domains of life. Currently, large-scale glycoproteomics approaches rely on glycan database dependent algorithms and are thus unsuitable for discovery-driven analyses of glycoproteomes. Therefore, we devised SugarPy, a glycan database independent Python module, and validated it on the glycoproteome of human breast milk. We further demonstrated its applicability by analyzing glycoproteomes with uncommon glycans stemming from the green algae Chalmydomonas reinhardtii and the archaeon Haloferax volcanii. Finally, SugarPy facilitated the novel characterization of glycoproteins from Cyanidioschyzon merolae. |
HostingRepository | PRIDE |
AnnounceDate | 2021-03-09 |
AnnouncementXML | Submission_2021-03-09_11:05:13.891.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Stefan Schulze |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Cyanidioschyzon merolae; NCBI TaxID: 45157; scientific name: Chlamydomonas reinhardtii; NCBI TaxID: 3055; scientific name: Haloferax volcanii; NCBI TaxID: 2246; |
ModificationList | monohydroxylated residue; complex glycosylation; iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-01-31 01:45:44 | ID requested | |
⏵ 1 | 2021-03-09 11:05:14 | announced | |
Publication List
Schulze S, Oltmanns A, Fufezan C, Kr, ä, genbring J, Mormann M, Pohlschr, ö, der M, Hippler M, SugarPy facilitates the universal, discovery-driven analysis of intact glycopeptides. Bioinformatics, 36(22-23):5330-5336(2021) [pubmed] |
Keyword List
submitter keyword: SugarPy, computational proteomics, glycoproteomics, glycosylation, IS-CID, LC-MS/MS, human breast milk, microalgae, archaea |
Contact List
Michael Hippler |
contact affiliation | Institute of Plant Biology and Biotechnology, University of Münster, 48143 Münster, Germany |
contact email | mhippler@uni-muenster.de |
lab head | |
Stefan Schulze |
contact affiliation | University of Pennsylvania |
contact email | sschulze@sas.upenn.edu |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD017345
- Label: PRIDE project
- Name: SugarPy facilitates the universal, discovery-driven analysis of intact glycopeptides