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PXD017328

PXD017328 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleStress enhances secretory autophagy increasing extracellular Bdnf maturation
DescriptionStress response is a fundamental mechanism to maintain a healthy homeostasis and its disruption is implicated in several psychiatric disorders. Autophagy is one of the mechanisms regulating homeostasis, and it is known to be activated by cellular stressors such as starvation. In a previous study, we revealed that glucocorticoid (GC)-mediated stress also activates macroautophagy via the stress-responsive co-chaperone FK506-binding protein 51 (FKBP51). In this study we reveal that GC-mediated stress enhances secretory autophagy, a recently described Atg-dependent secretory pathway, via FKBP51. Strikingly we detected the matrix metallopeptidase 9 (Mmp9) as one of the stress-induced secreted proteins. Furthermore we found that enhanced Mmp9 secretion increases both in vitro and in vivo the cleavage of pro-brain derived neurotrophic factor (proBdnf) to its mature form (mBdnf), a key protein in neuroplasticity. This unravelled mechanism can represent a link between stress and the development of psychiatric disorders.
HostingRepositoryPRIDE
AnnounceDate2021-08-26
AnnouncementXMLSubmission_2021-08-26_06:46:03.024.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD017328
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterGiuseppina Maccarrone
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-01-29 23:58:23ID requested
12021-08-26 06:46:03announced
Publication List
Martinelli S, Anderzhanova EA, Bajaj T, Wiechmann S, Dethloff F, Weckmann K, Heinz DE, Ebert T, Hartmann J, Geiger TM, D, ö, ngi M, Hafner K, P, ö, hlmann ML, Jollans L, Philipsen A, Schmidt SV, Schmidt U, Maccarrone G, Stein V, Hausch F, Turck CW, Schmidt MV, Gellner AK, Kuster B, Gassen NC, Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nat Commun, 12(1):4643(2021) [pubmed]
Keyword List
submitter keyword: Human, LC-MSMS, interactome
Contact List
Maccarrone Giuseppina
contact affiliationDepartment of Translational Research in Psychiatry, Proteomics Core Unit, Max Planck Institute of Psychiatry, Germany
contact emailmaccarrone@psych.mpg.de
lab head
Giuseppina Maccarrone
contact affiliationMax Planck Institute of Psychiatry
contact emailmaccarrone@psych.mpg.de
dataset submitter
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Dataset FTP location
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