PXD017274

PXD017274 is an original dataset announced via ProteomeXchange.

Title	The porcine granulocyte proteome: expression changes in a transgenic pig model for diabetes
Description	As transgenic INSC94Y-pigs develop a stable diabetic phenotype we were able to study the influence of elevated blood glucose levels on primary immune cells in vivo. We investigated the neutrophil proteome and compared data of transgenic animals to a control group. A total of 2371 proteins describing the whole neutrophil proteome were identified, including 396 proteins (17% of proteome) newly associated to expression in porcine neutrophils. Our studies provide novel information on the porcine granulocyte proteome and contribute to a better understanding of molecular mechanisms involved in altered immune cell function in diabetes. The data presented here is highly relevant for veterinary medicine and has translational quality for diabetes in human.
HostingRepository	PRIDE
AnnounceDate	2020-06-04
AnnouncementXML	Submission_2020-06-04_03:22:09.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roxane Degroote
SpeciesList	scientific name: Sus scrofa domesticus (domestic pig); NCBI TaxID: 9825;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2020-01-24 03:31:09	ID requested
⏵ 1	2020-06-04 03:28:55	announced

Weigand M, Degroote RL, Amann B, Renner S, Wolf E, Hauck SM, Deeg CA, Proteome profile of neutrophils from a transgenic diabetic pig model shows distinct changes. J Proteomics, 224():103843(2020) [pubmed]

submitter keyword: differential proteomics, diabetes, innate immune cell, neutrophil granulocyte

Cornelia Annette Deeg
contact affiliation	Chair of Animal Physiology, Veterinary Sciences, LMU Munich, Germany
contact email	Cornelia.Deeg@lmu.de
lab head
Roxane Degroote
contact affiliation	Ludwig-Maximilians-University Munich, Chair of Animal Physiology, Veterinaerstrasse 13, 80539, Munich, Germany
contact email	r.degroote@lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/06/PXD017274

PRIDE project URI

• PRIDE
  1. PXD017274
     1. Label: PRIDE project
     2. Name: The porcine granulocyte proteome: expression changes in a transgenic pig model for diabetes